RhoA is activated by nucleotide exchange and inhibits axonal growth

Stable Identifier
R-HSA-194518
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RHOA is activated by guanine nucleotide exchange factors (RhoGEFs), exchanging GDP for GTP. RHOA, activated following binding of MDGIs (RTN4, MAG or OMG) to the complex of NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), rigidifies the actin cytoskeleton, thereby inhibiting axonal elongation and causing growth cone collapse. MCF2 (Dbl) RHO GEF was used to demonstrate activation of RHOA downstream of NGFR and RTN4R-mediated sequestration of ARHGDIA, a RHO-GDI, but other RHO GEFs may also be involved in RHOA activation (Yamashita and Tohyama 2003).

Literature References
PubMed ID Title Journal Year
12692556 The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI Nat Neurosci 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of MCF2(1-925) [cytosol]
Physical Entity
Activity
Orthologous Events