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RTN4 [plasma membrane]
Stable Identifier
R-HSA-194556
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NOGO, Reticulon 4, RTN4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth inhibition (RHOA activation) (Homo sapiens)
Myelin components can interact with p75NTR:NgR:LINGO1 (Homo sapiens)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)
ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4,MAG,OMG [plasma membrane] (Homo sapiens)
RTN4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQC3 RTN4
Gene Names
RTN4, KIAA0886, NOGO, My043, SP1507
Chain
chain:1-1192
Reference Genes
BioGPS Gene:57142 RTN4
COSMIC (genes):RTN4 RTN4
CTD Gene:57142 RTN4
dbSNP Gene:57142 RTN4
ENSEMBL:ENSG00000115310 RTN4
HGNC:14085 RTN4
KEGG Gene (Homo sapiens):57142 RTN4
Monarch:57142 RTN4
NCBI Gene:57142 RTN4
OMIM:604475 RTN4
UCSC:Q9NQC3 RTN4
Reference Transcript
RefSeq:NM_153828.2 RTN4
RefSeq:NM_001321862.1 RTN4
RefSeq:XM_017004518.1 RTN4
RefSeq:XM_005264434.3 RTN4
RefSeq:NM_007008.2 RTN4
RefSeq:NM_020532.4 RTN4
RefSeq:NM_001321861.1 RTN4
RefSeq:NM_001321904.1 RTN4
RefSeq:NM_001321860.1 RTN4
RefSeq:NM_207521.1 RTN4
RefSeq:NM_001321863.1 RTN4
RefSeq:XM_017004519.1 RTN4
RefSeq:NM_001321859.1 RTN4
RefSeq:NM_207520.1 RTN4
Other Identifiers
0000060546
0002850390
11718592_s_at
11718593_x_at
11719933_x_at
11738035_s_at
11744360_x_at
11749059_x_at
11752131_a_at
11753588_x_at
16897637
210968_s_at
211509_s_at
214629_x_at
2553581
2553582
2553583
2553584
2553585
2553586
2553587
2553588
2553589
2553590
2553591
2553593
2553595
2553597
2553610
2553614
2553615
2553620
2553621
2553622
2553628
2553629
2553630
2553631
2553633
2553640
2553643
2553647
2553648
2553649
2553650
2553651
2553652
31536_at
57142
8052204
A_23_P56933
A_33_P3233550
GE53561
GE663571
GE80778
GO:0000902
GO:0001825
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006915
GO:0007165
GO:0007399
GO:0007413
GO:0008150
GO:0008219
GO:0008283
GO:0009790
GO:0010634
GO:0014069
GO:0016020
GO:0016021
GO:0019899
GO:0021801
GO:0022607
GO:0030054
GO:0030154
GO:0030176
GO:0030308
GO:0030517
GO:0031625
GO:0033601
GO:0034165
GO:0040007
GO:0040011
GO:0042592
GO:0042981
GO:0042995
GO:0043025
GO:0043226
GO:0045296
GO:0048646
GO:0048856
GO:0048870
GO:0050771
GO:0050821
GO:0051292
GO:0051897
GO:0051960
GO:0060317
GO:0061024
GO:0061462
GO:0065003
GO:0071782
GO:0071786
GO:0071787
GO:0090156
GO:0098826
GO:1905552
GO:1905580
GO:1990809
GO:2000172
Hs.65450.7.A2_3p_a_at
ILMN_1693598
ILMN_1730611
ILMN_1748983
ILMN_2352036
PH_hs_0025494
TC02004241.hg
g5821139_3p_a_at
Participant Of
hasMember
RTN4,MAG,OMG [plasma membrane]
Inferred To
Rtn4 [plasma membrane] (Mus musculus)
Rtn4 [plasma membrane] (Rattus norvegicus)
rtn4a [plasma membrane] (Danio rerio)
RTN4 [plasma membrane] (Canis familiaris)
RTN4 [plasma membrane] (Sus scrofa)
RTN4 [plasma membrane] (Xenopus tropicalis)
Rtnl1 [plasma membrane] (Drosophila melanogaster)
Cross References
RefSeq
XP_016860007.1
,
NP_001308791.1
,
NP_001308792.1
,
NP_722550.1
,
NP_065393.1
,
NP_008939.1
,
NP_997403.1
,
NP_997404.1
,
NP_001308833.1
,
XP_016860008.1
,
NP_001308788.1
,
NP_001308790.1
,
XP_005264491.1
,
NP_001308789.1
OpenTargets
ENSG00000115310
GeneCards
Q9NQC3
HPA
ENSG00000115310-RTN4
Ensembl
ENST00000405240
,
ENSG00000115310
,
ENST00000317610
,
ENSP00000337838
,
ENSP00000385650
,
ENSP00000384471
,
ENST00000394609
,
ENST00000337526
,
ENSP00000378107
,
ENSP00000350365
,
ENST00000404909
,
ENSP00000378109
,
ENST00000394611
,
ENSP00000322147
,
ENSP00000349944
,
ENST00000357376
,
ENST00000357732
PRO
Q9NQC3
PDB
2G31
,
2JV5
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC5 M
8
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
M [virion membrane]
(R-COV-9694320)
N-glycan M [virion membrane]
(R-COV-9694385)
0.643
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.558
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.553
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
4
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