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SYT1 [synaptic vesicle membrane]
Stable Identifier
R-HSA-194789
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
synaptic vesicle membrane
Synonyms
Synaptotagmin 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type B (botB) (Homo sapiens)
botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SYT1,2 [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
botB HC:LC:SYT:GT1b [synaptic vesicle membrane] (Homo sapiens)
SYT1,2 [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
botB HC:LC:SYT:GT1b [synaptic vesicle membrane] (Homo sapiens)
SYT1,2 [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type G (botG) (Homo sapiens)
botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
botG:SYT1:GT1b [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
botG:SYT1:GT1b [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
NRXNs bind SYTs (Homo sapiens)
NRXNs:SYT [plasma membrane] (Homo sapiens)
SYT [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
SYT [synaptic vesicle membrane] (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21579 SYT1
Gene Names
SYT1, SVP65, SYT
Chain
chain:1-422
Reference Genes
BioGPS Gene:6857 SYT1
COSMIC (genes):SYT1 SYT1
CTD Gene:6857 SYT1
dbSNP Gene:6857 SYT1
ENSEMBL:ENSG00000067715 SYT1
HGNC:11509 SYT1
KEGG:hsa:6857 SYT1
Monarch:6857 SYT1
NCBI Gene:6857 SYT1
OMIM:185605 SYT1
UCSC:P21579 SYT1
Reference Transcript
RefSeq:XM_017019909.1 SYT1
RefSeq:NM_001135806.1 SYT1
RefSeq:XM_011538710.1 SYT1
RefSeq:NM_001135805.1 SYT1
RefSeq:NM_005639.2 SYT1
Other Identifiers
11724585_a_at
11724586_a_at
11724587_a_at
16754536
203998_PM_s_at
203998_s_at
203999_PM_at
203999_at
3254781
3423629
3423630
3423631
3423632
3423633
3423634
3423635
3423638
3423648
3423649
3423653
3423659
3423663
3423675
3423676
3423705
3423721
3423722
3423723
3423724
3423725
3423736
3423751
3423752
3423753
3423754
40075_at
6857
7957338
A_14_P100506
A_14_P133211
A_23_P36795
A_33_P3237201
GE57966
GO:0000149
GO:0001786
GO:0005509
GO:0005513
GO:0005515
GO:0005516
GO:0005543
GO:0005544
GO:0005546
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006906
GO:0007268
GO:0007269
GO:0008021
GO:0008289
GO:0014059
GO:0014069
GO:0016020
GO:0016050
GO:0016079
GO:0016192
GO:0017075
GO:0017157
GO:0017158
GO:0019905
GO:0023052
GO:0030141
GO:0030154
GO:0030276
GO:0030348
GO:0030424
GO:0030669
GO:0030672
GO:0031045
GO:0031338
GO:0031340
GO:0031410
GO:0033603
GO:0042584
GO:0042734
GO:0042802
GO:0043005
GO:0043226
GO:0044306
GO:0045202
GO:0045211
GO:0045956
GO:0046872
GO:0046982
GO:0048278
GO:0048306
GO:0048488
GO:0048786
GO:0048791
GO:0050750
GO:0050806
GO:0051291
GO:0051592
GO:0051966
GO:0060076
GO:0060090
GO:0060201
GO:0060203
GO:0061024
GO:0061202
GO:0061669
GO:0061891
GO:0065003
GO:0070083
GO:0070382
GO:0071277
GO:0071911
GO:0098686
GO:0098746
GO:0098978
GO:0099502
GO:0099523
GO:0099524
GO:0140299
GO:0140693
GO:0140694
GO:1903235
GO:1903305
GO:1903861
GO:2000300
HMNXSV003056582
Hs.154679.0.S1_3p_a_at
Hs.154679.0.S3_3p_at
ILMN_1742881
ILMN_1838187
M55047_at
PH_hs_0009313
TC12000660.hg
Participates
as a member of
SYT1,2 [synaptic vesicle membrane] (Homo sapiens)
as an output of
botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
as a component of
botG:SYT1:GT1b [synaptic vesicle membrane] (Homo sapiens)
as a candidate of
SYT [synaptic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
SYT1 [plasma membrane]
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
SYT1 [clathrin-coated endocytic vesicle membrane]
Cross References
RefSeq
NP_005630.1
,
NP_001129278.1
,
NP_001129277.1
,
XP_011537012.1
,
XP_016875398.1
OpenTargets
ENSG00000067715
ENSEMBL
ENST00000704700
,
ENST00000261205
,
ENST00000393240
,
ENSP00000261205
,
ENSP00000447575
,
ENSP00000376932
,
ENST00000704706
,
ENST00000704708
,
ENST00000704705
,
ENST00000704702
,
ENST00000704704
,
ENSP00000516013
,
ENST00000704710
,
ENSP00000516009
,
ENSP00000515997
,
ENSP00000515999
,
ENST00000704696
,
ENST00000704718
,
ENSP00000516005
,
ENST00000552744
,
ENSP00000516007
,
ENST00000704714
,
ENSP00000516001
,
ENSP00000515993
,
ENSP00000516003
,
ENSP00000516002
HPA
ENSG00000067715-SYT1
PRO
P21579
Pharos - Targets
P21579
GlyGen
P21579
Orphanet
SYT1
HMDB Protein
HMDBP08028
PDB
6G5F
,
4V11
,
2KI6
,
2K4A
,
7TUA
,
6U4W
,
8B8I
,
4ISQ
,
7U4Q
,
3F00
,
6U4U
,
3F05
,
6QNS
,
2LHA
,
2K45
,
2N1T
,
2R83
,
2K8M
,
3F01
,
6G5K
,
6ZVN
,
6U41
,
6TZ3
,
3F04
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N9I0 SYT2
3
SYT2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869116)
SYT2 [plasma membrane]
(R-HSA-168795)
SYT2 [synaptic vesicle membrane]
(R-HSA-194786)
0.623
4
UniProt:Q9Y6K9 IKBKG
12
IKBKG [cytosol]
(R-HSA-168108)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
IKBKG [nucleoplasm]
(R-HSA-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
0.581
3
UniProt:Q12982 BNIP2
1
BNIP2 [cytosol]
(R-HSA-200792)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.556
3
UniProt:O43169 CYB5B
2
CYB5B [endoplasmic reticulum membrane]
(R-HSA-9842695)
CYB5B [mitochondrial outer membrane]
(R-HSA-8943390)
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:O95159 ZFPL1
0.556
3
UniProt:P30301 MIP
1
MIP [plasma membrane]
(R-HSA-432026)
0.556
3
UniProt:Q9P0S9 TM14C
0.556
3
UniProt:P30519 HMOX2
3
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [plasma membrane]
(R-HSA-6799676)
0.556
3
UniProt:Q8TBM7 TM254
0.556
3
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.556
3
UniProt:Q8N6G5 CSGALNACT2
1
CSGALNACT2 [Golgi membrane]
(R-HSA-1971506)
0.556
3
UniProt:Q9H2L4 TMM60
0.556
3
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.527
2
UniProt:O00445 SYT5
1
SYT5 [secretory granule membrane]
(R-HSA-265193)
0.527
3
UniProt:Q13144 EIF2B5
1
EIF2B5 [cytosol]
(R-HSA-72523)
0.527
3
UniProt:Q9UHK0 NUFP1
0.527
2
UniProt:Q9NR50 EIF2B3
1
EIF2B3 [cytosol]
(R-HSA-72525)
0.527
2
UniProt:Q53HL2 CDCA8
3
polySUMO2,3-CDCA8 [cytosol]
(R-HSA-4655328)
CDCA8 [nucleoplasm]
(R-HSA-4655357)
CDCA8 [cytosol]
(R-HSA-375288)
0.527
2
UniProt:Q9NVT9 ARMC1
0.527
2
UniProt:P07205 PGK2
1
PGK2 [cytosol]
(R-HSA-6807622)
0.527
2
UniProt:O00305-2 CACNB4
0.527
2
UniProt:P49770 EIF2B2
1
EIF2B2 [cytosol]
(R-HSA-72519)
0.527
3
UniProt:Q9Y3A4 RRP7A
1
RRP7A [nucleoplasm]
(R-HSA-6790723)
0.527
2
UniProt:P16473 TSHR
1
TSHR [plasma membrane]
(R-HSA-391371)
0.508
2
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