Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SYT1 [synaptic vesicle membrane]
Stable Identifier
R-HSA-194789
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
synaptic vesicle membrane
Synonyms
Synaptotagmin 1
Locations in the PathwayBrowser for interactor UniProt:P30519%20HMOX2
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type G (botG) (Homo sapiens)
botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SYT1 [synaptic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21579 SYT1
Gene Names
SYT1, SVP65, SYT
Chain
chain:1-422
Reference Genes
BioGPS Gene:6857 SYT1
COSMIC (genes):SYT1 SYT1
CTD Gene:6857 SYT1
dbSNP Gene:6857 SYT1
ENSEMBL:ENSG00000067715 SYT1
ENSEMBL_homo_sapiens_GENE:ENSG00000067715.15 SYT1
HGNC:11509 SYT1
KEGG Gene (Homo sapiens):6857 SYT1
Monarch:6857 SYT1
NCBI Gene:6857 SYT1
OMIM:185605 SYT1
UCSC:P21579 SYT1
Reference Transcript
RefSeq:NM_001135805.1 SYT1
RefSeq:XM_011538710.1 SYT1
RefSeq:NM_005639.2 SYT1
RefSeq:XM_017019909.1 SYT1
RefSeq:NM_001135806.1 SYT1
Other Identifiers
11724585_a_at
11724586_a_at
11724587_a_at
16754536
203998_PM_s_at
203998_s_at
203999_PM_at
203999_at
3254781
3423629
3423630
3423631
3423632
3423633
3423634
3423635
3423648
3423649
3423653
3423663
3423676
3423705
3423721
3423722
3423723
3423724
3423725
3423736
3423751
3423753
3423754
40075_at
6857
7957338
A_14_P100506
A_23_P36795
A_33_P3237201
GE57966
GO:0000149
GO:0001786
GO:0005509
GO:0005513
GO:0005515
GO:0005516
GO:0005543
GO:0005544
GO:0005546
GO:0005737
GO:0005794
GO:0005886
GO:0007268
GO:0007269
GO:0008021
GO:0008289
GO:0014059
GO:0016020
GO:0016079
GO:0016192
GO:0017075
GO:0017157
GO:0017158
GO:0019905
GO:0023052
GO:0030141
GO:0030154
GO:0030276
GO:0030348
GO:0030424
GO:0030658
GO:0030669
GO:0030672
GO:0031045
GO:0031340
GO:0031410
GO:0033603
GO:0042584
GO:0042734
GO:0042802
GO:0043005
GO:0043226
GO:0044306
GO:0045202
GO:0045956
GO:0046872
GO:0046982
GO:0048278
GO:0048306
GO:0048488
GO:0048791
GO:0048856
GO:0050750
GO:0050806
GO:0051291
GO:0051592
GO:0051966
GO:0060076
GO:0060201
GO:0060203
GO:0061024
GO:0061202
GO:0061669
GO:0061891
GO:0065003
GO:0070083
GO:0070382
GO:0071277
GO:0071911
GO:0098686
GO:0098746
GO:0098978
GO:0099502
GO:0140299
GO:1903235
GO:1903305
GO:1903861
GO:2000300
HMNXSV003056582
Hs.154679.0.S1_3p_a_at
Hs.154679.0.S3_3p_at
ILMN_1742881
ILMN_1838187
M55047_at
PH_hs_0009313
TC12000660.hg
Participates
as a member of
SYT1,2 [synaptic vesicle membrane] (Homo sapiens)
as an output of
botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
as a component of
botG:SYT1:GT1b [synaptic vesicle membrane] (Homo sapiens)
as a candidate of
SYT [synaptic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SYT1 [clathrin-coated endocytic vesicle membrane]
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
SYT1 [plasma membrane]
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
Cross References
RefSeq
XP_016875398.1
,
NP_001129277.1
,
NP_001129278.1
,
XP_011537012.1
,
NP_005630.1
OpenTargets
ENSG00000067715
HPA
ENSG00000067715-SYT1
GeneCards
P21579
Ensembl
ENST00000704700
,
ENSP00000516013
,
ENST00000704705
,
ENST00000704702
,
ENST00000704704
,
ENST00000704706
,
ENST00000704708
,
ENSP00000261205
,
ENSP00000516001
,
ENSP00000516003
,
ENSP00000516002
,
ENST00000704710
,
ENSP00000515993
,
ENSP00000516005
,
ENST00000261205
,
ENST00000393240
,
ENST00000704714
,
ENSP00000516007
,
ENST00000552744
,
ENST00000704696
,
ENSP00000515997
,
ENSP00000516009
,
ENST00000704718
,
ENSP00000376932
,
ENSP00000515999
,
ENSG00000067715
,
ENSP00000447575
PRO
P21579
Pharos - Targets
P21579
Orphanet
24960
HMDB Protein
HMDBP08028
PDB
2K45
,
6U41
,
2K8M
,
4V11
,
6G5F
,
6TZ3
,
2LHA
,
6G5K
,
3F04
,
6QNS
,
2K4A
,
7U4Q
,
4ISQ
,
3F01
,
2N1T
,
2KI6
,
3F05
,
2R83
,
6U4U
,
6ZVN
,
3F00
,
6U4W
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.581
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:Q9P0S9 TM14C
0.556
3
UniProt:Q9H2L4 TMM60
0.556
3
UniProt:Q8N6G5 CSGALNACT2
1
CSGALNACT2 [Golgi membrane]
(R-HSA-1971506)
0.556
3
UniProt:P30301 MIP
1
MIP [plasma membrane]
(R-HSA-432026)
0.556
3
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.556
3
UniProt:Q8TBM7 TM254
0.556
3
UniProt:O95159 ZFPL1
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:O43169 CYB5B
2
CYB5B [mitochondrial outer membrane]
(R-HSA-8943390)
CYB5B [endoplasmic reticulum membrane]
(R-HSA-9842695)
0.556
3
UniProt:P30519 HMOX2
3
HMOX2 [plasma membrane]
(R-HSA-6799676)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
0.556
3
UniProt:Q12982 BNIP2
1
BNIP2 [cytosol]
(R-HSA-200792)
0.556
3
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.556
3
UniProt:O00305-2 CACNB4
0.527
2
UniProt:P16473 TSHR
1
TSHR [plasma membrane]
(R-HSA-391371)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text