botC LC cleaves target cell SNAP25

Stable Identifier
R-HSA-194793
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
cytosol, plasma membrane
Synonyms
BoNT Light Chain Type C1 cleaves SNAP-25
ReviewStatus
5/5
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botC LC cleaves target cell SNAP25
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Botulinum toxin type C light chain (botC LC), in the cytosol of a target cell, catalyzes the removal of a carboxyterminal peptide from synaptosomal associated protein 25 (SNAP25). botC LC is a zinc metalloprotease (Foran et al. 1994; Vaidyanathan et al. 1999). SNAP25 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).
Literature References
PubMed ID Title Journal Year
8611567 Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

Foran, P, Lawrence, GW, Shone, CC, Foster, KA, Dolly, JO

Biochemistry 1996
8402889 Membrane fusion machinery: insights from synaptic proteins

Südhof, TC, De Camilli, P, Niemann, H, Jahn, R

Cell 1993
9886085 Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage

Vaidyanathan, VV, Yoshino, K, Jahnz, M, Dorries, C, Bade, S, Nauenburg, S, Niemann, H, Binz, T

J Neurochem 1999
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of botC LC:Zn2+ [cytosol]

Physical Entity
botC LC:Zn2+ [cytosol] (Clostridium botulinum)
Activity
metalloendopeptidase activity (GO:0004222)
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Cross References
Mondo
Authored
Krupa, S  (2006-06-15)
Gopinathrao, G  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
Gopinathrao, G  (2007-03-27)
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