GEFs activate Rho GTPase:GDP

Stable Identifier
R-HSA-194913
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

Literature References
PubMed ID Title Journal Year
7954831 Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor

Pasteris, NG, Cadle, A, Logie, LJ, Porteous, ME, Schwartz, CE, Stevenson, RE, Glover, TW, Wilroy, RS, Gorski, JL

Cell 1994
8810315 Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

Hart, MJ, Sharma, S, elMasry, N, Qiu, RG, McCabe, P, Polakis, P, Bollag, G

J Biol Chem 1996
9308960 Rho GTPases and signaling networks

Van Aelst, L, D'Souza-Schorey, C

Genes Dev 1997
16212495 Rho GTPases: biochemistry and biology

Jaffe, AB, Hall, A

Annu Rev Cell Dev Biol 2005
8276860 Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product

Hart, MJ, Eva, A, Zangrilli, D, Aaronson, SA, Evans, T, Cerione, RA, Zheng, Y

J Biol Chem 1994
9857026 Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

Ren, Y, Li, R, Zheng, Y, Busch, H

J Biol Chem 1998
10559246 Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

Reid, T, Bathoorn, A, Ahmadian, MR, Collard, JG

J Biol Chem 1999
8969170 The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

Zheng, Y, Fischer, DJ, Santos, MF, Tigyi, G, Pasteris, NG, Gorski, JL, Xu, Y

J Biol Chem 1996
12101119 Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

Schmidt, A, Hall, A

Genes Dev 2002
7478592 The proline-rich region of Vav binds to Grb2 and Grb3-3

Ramos-Morales, F, Romero, F, Schweighoffer, F, Bismuth, G, Camonis, J, Tortolero, M, Fischer, S

Oncogene 1995
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Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of GEFs [cytosol]
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Activity
Orthologous Events
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Created