Reactome | TIAM1 [cytosol]

TIAM1 [cytosol]

Stable Identifier

R-HSA-195013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tiam1

Locations in the PathwayBrowser for interactor UniProt:P54763

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK2 (TRKB) (Homo sapiens)
      - Activated NTRK2 signals through CDK5 (Homo sapiens)
        
        NTRK2 binds TIAM1 (Homo sapiens)
        
        TIAM1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13009 TIAM1

Gene Names

TIAM1

Chain

initiator methionine:, chain:2-1591

Reference Genes

BioGPS Gene:7074 TIAM1

COSMIC (genes):TIAM1 TIAM1

CTD Gene:7074 TIAM1

dbSNP Gene:7074 TIAM1

ENSEMBL:ENSG00000156299 TIAM1

ENSEMBL_homo_sapiens_GENE:ENSG00000156299.15 TIAM1

HGNC:11805 TIAM1

KEGG Gene (Homo sapiens):7074 TIAM1

Monarch:7074 TIAM1

NCBI Gene:7074 TIAM1

OMIM:600687 TIAM1

UCSC:Q13009 TIAM1

Reference Transcript

Other Identifiers

11732415_s_at

11732416_a_at

16924878

206409_PM_at

206409_at

213135_PM_at

213135_at

37460_at

38370_at

3928667

3928670

3928671

3928672

3928673

3928674

3928675

3928678

3928679

3928681

3928682

3928683

3928685

3928686

3928687

3928691

3928692

3928693

3928698

3928702

3928703

3928705

3928708

3928709

3928710

3928713

3928715

3928717

3928718

3928719

3928721

3928722

3928723

3928730

3928734

3928735

3928748

3928759

3928783

7074

8069880

A_23_P17624

A_33_P3381751

GE58965

GE59547

GO:0003012

GO:0003300

GO:0005085

GO:0005515

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005911

GO:0007155

GO:0007160

GO:0007165

GO:0007264

GO:0008017

GO:0008092

GO:0008284

GO:0008289

GO:0010717

GO:0010718

GO:0010976

GO:0016020

GO:0016477

GO:0016601

GO:0019900

GO:0023052

GO:0030154

GO:0030335

GO:0030695

GO:0030971

GO:0032092

GO:0032587

GO:0034330

GO:0035556

GO:0036477

GO:0042220

GO:0043025

GO:0043197

GO:0043226

GO:0044291

GO:0044295

GO:0044304

GO:0045202

GO:0048013

GO:0048856

GO:0048870

GO:0050772

GO:0051056

GO:0060071

GO:0061003

GO:0061178

GO:0065003

GO:0070161

GO:0070372

GO:0072657

GO:0090630

GO:0098772

GO:0098978

GO:0099147

GO:0099175

GO:1904268

GO:1904338

GO:1905274

GO:1990138

GO:2000050

HMNXSV003047589

HMNXSV003054829

Hs.82141.0.S1_3p_at

ILMN_1655577

PH_hs_0006311

TC21000388.hg

U16296_at

U90902_at

g4507500_3p_at

Participates

as a candidate of

as a member of

as an input of

as a component of

Other forms of this molecule

p-Y829-TIAM1 [cytosol]

Inferred To

gxcF [cytosol] (Dictyostelium discoideum)

tiam1 [cytosol] (Xenopus tropicalis)

Tiam1 [cytosol] (Mus musculus)

Tiam1 [cytosol] (Rattus norvegicus)

tiam-1 [cytosol] (Caenorhabditis elegans)

TIAM1 [cytosol] (Canis familiaris)

TIAM1 [cytosol] (Gallus gallus)

TIAM1 [cytosol] (Sus scrofa)

Ghost homologue of TIAM1 [cytosol] (Bos taurus)

Ghost homologue of TIAM1 [cytosol] (Danio rerio)

sif [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_005261095.1, XP_016883937.1, XP_016883940.1, XP_016883938.1, XP_011528015.1, XP_005261094.1, XP_016883941.1, XP_011528014.1, XP_016883939.1, XP_016883942.1, XP_016883936.1, XP_011528013.1, NP_003244.2

OpenTargets

ENSG00000156299

GeneCards

Q13009

HPA

ENSG00000156299-TIAM1

Ensembl

ENSP00000286827, ENSP00000441570, ENSP00000388217, ENST00000541036, ENST00000455508, ENST00000286827, ENSG00000156299

PRO

Q13009

Pharos - Targets

Q13009

HMDB Protein

HMDBP08608

PDB

3KZE, 2D8I, 4NXQ, 4NXP, 3KZD, 4GVD, 4NXR, 4K2P, 4GVC, 4K2O

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.749	4
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.678	3
UniProt:P18827 SDC1	20	SDC1 [lysosomal lumen] (R-HSA-2090025) HS(6)-SDC1 [lysosomal lumen] (R-HSA-2090082) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) SDC1 [Golgi lumen] (R-HSA-2054105) HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672)	0.655	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	3
UniProt:Q9C0A0-1 CNTNAP4			0.558	2
UniProt:P54763 Ephb2	9	phospho-p-Y596,Y602-EPHB2 [plasma membrane] (R-MMU-3928375) p-Ephb2 [plasma membrane] (R-MMU-3928433) EPHB2 [plasma membrane] (R-MMU-443809) EPHB2 (19-?) [extracellular region] (R-MMU-3928436) EPHB2 (?-1055) [plasma membrane] (R-MMU-3928386) EPHB2 (?-1055) [cytosol] (R-MMU-3928432) P54763 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.524	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.483	2

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