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ARHGEF6 [cytosol]
Stable Identifier
R-HSA-195017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alpha-Pix, PIX alpha, Cool-2
Locations in the PathwayBrowser for interactor UniProt:Q9BYV2 TRI54
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
PARVB/Affixin interacts with alpha PIX (Homo sapiens)
ARHGEF6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through CDC42 (Homo sapiens)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)
ARHGEF6 [cytosol] (Homo sapiens)
PAK1 binds ARHGEF6 (Homo sapiens)
ARHGEF6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15052 ARHGEF6
Gene Names
ARHGEF6, COOL2, KIAA0006, PIXA
Chain
chain:1-776
Reference Genes
BioGPS Gene:9459 ARHGEF6
COSMIC (genes):ARHGEF6 ARHGEF6
CTD Gene:9459 ARHGEF6
dbSNP Gene:9459 ARHGEF6
ENSEMBL:ENSG00000129675 ARHGEF6
HGNC:685 ARHGEF6
KEGG Gene (Homo sapiens):9459 ARHGEF6
Monarch:9459 ARHGEF6
NCBI Gene:9459 ARHGEF6
OMIM:300267 ARHGEF6
UCSC:Q15052 ARHGEF6
Reference Transcript
RefSeq:NM_004840.2 ARHGEF6
RefSeq:NM_001306177.1 ARHGEF6
Other Identifiers
0006520711
11723368_a_at
11752189_a_at
11752825_a_at
17114520
209539_at
37543_at
4023468
4023469
4023470
4023471
4023472
4023474
4023476
4023479
4023482
4023483
4023484
4023485
4023486
4023487
4023488
4023489
4023490
4023492
4023498
4023500
4023501
4023502
4023511
4023512
4023517
4023520
4023521
4023522
8175393
9459
A_23_P85024
A_24_P228875
D13631_s_at
D25304_at
GE57127
GO:0003674
GO:0005085
GO:0005089
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0006915
GO:0006950
GO:0007165
GO:0007186
GO:0007254
GO:0008150
GO:0008219
GO:0019899
GO:0022607
GO:0030027
GO:0030032
GO:0030234
GO:0042995
GO:0043065
GO:0043547
GO:0051056
Hs.79307.0.S2_3p_at
ILMN_1803423
PH_hs_0024220
TC0X001416.hg
Participant Of
output
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
hasComponent
Active PAK1:ARHGEF6 [cytosol]
PAK1:ARHGEF6 [cytosol]
ParvB/Affixin:Alpha-Pix [cytosol]
input
PAK1 binds ARHGEF6
PARVB/Affixin interacts with alpha PIX
hasMember
GEFs [cytosol]
Inferred To
pix-1 [cytosol] (Caenorhabditis elegans)
Arhgef6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Rattus norvegicus)
arhgef6 [cytosol] (Danio rerio)
arhgef6 [cytosol] (Xenopus tropicalis)
RtGEF [cytosol] (Drosophila melanogaster)
ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Gallus gallus)
ARHGEF6 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_004831.1
,
NP_001293106.1
OpenTargets
ENSG00000129675
GeneCards
Q15052
HPA
ENSG00000129675-ARHGEF6
Ensembl
ENST00000370622
,
ENSG00000129675
,
ENSP00000359656
,
ENST00000370620
,
ENSP00000250617
,
ENSP00000359654
,
ENST00000250617
PRO
Q15052
Orphanet
17746
HMDB Protein
HMDBP11457
PDB
1UJY
,
1WYR
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
0.709
5
UniProt:Q13153 PAK1
6
p-S144-PAK1 [cytosol]
(R-HSA-451339)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.659
4
UniProt:Q14161-11 GIT2
0.631
9
UniProt:O60880-1 SH2D1A
0.581
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
IntAct:EBI-22384398 CCSB ORF ID
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:P78424 PO6F2
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
IntAct:EBI-22314709 CCSB ORF ID
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q9UIY3 RWD2A
0.556
3
UniProt:P41227 NAA10
0.524
3
UniProt:Q15599 NHRF2
0.508
2
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