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ECT2 [cytosol]
Stable Identifier
R-HSA-195036
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ect2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ECT2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H8V3 ECT2
Gene Names
ECT2
Chain
initiator methionine:, chain:2-914
Reference Genes
BioGPS Gene:1894 ECT2
COSMIC (genes):ECT2 ECT2
CTD Gene:1894 ECT2
dbSNP Gene:1894 ECT2
ENSEMBL:ENSG00000114346 ECT2
ENSEMBL_homo_sapiens_GENE:ENSG00000114346.14 ECT2
HGNC:3155 ECT2
KEGG Gene (Homo sapiens):1894 ECT2
Monarch:1894 ECT2
NCBI Gene:1894 ECT2
OMIM:600586 ECT2
UCSC:Q9H8V3 ECT2
Reference Transcript
RefSeq:XM_011512514.2 ECT2
RefSeq:NM_001258315.1 ECT2
RefSeq:NM_001258316.1 ECT2
RefSeq:NM_018098.5 ECT2
Other Identifiers
11745833_s_at
11745834_a_at
16948021
1894
219787_PM_s_at
219787_s_at
234992_PM_x_at
234992_x_at
2652676
2652677
2652679
2652680
2652681
2652682
2652683
2652685
2652686
2652687
2652689
2652690
2652691
2652693
2652694
2652695
2652696
2652697
2652698
2652699
2652701
2652702
2652703
2652704
2652705
2652707
2652708
2652712
2652714
2652715
2652721
2652722
2652723
2674347
59461_at
74829_at
7894036
8083941
A_14_P115248
A_14_P134542
A_23_P44684
A_23_P9574
A_24_P366033
GE56789
GO:0000278
GO:0000281
GO:0000902
GO:0000910
GO:0005085
GO:0005096
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005923
GO:0005938
GO:0006886
GO:0006913
GO:0007010
GO:0007049
GO:0007059
GO:0007399
GO:0012501
GO:0015031
GO:0016604
GO:0023052
GO:0030154
GO:0030496
GO:0031267
GO:0032147
GO:0032154
GO:0032467
GO:0034330
GO:0035556
GO:0036211
GO:0042307
GO:0042803
GO:0043065
GO:0043123
GO:0043226
GO:0043547
GO:0045666
GO:0045859
GO:0048856
GO:0051056
GO:0051260
GO:0051301
GO:0051988
GO:0065003
GO:0070161
GO:0070301
GO:0070830
GO:0071277
GO:0071479
GO:0072686
GO:0090630
GO:0097149
GO:0098772
GO:2000431
HMNXSV003038075
HMNXSV003041715
ILMN_1717173
PH_hs_0028136
TC03000930.hg
g8922431_3p_a_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
Inferred To
ect-2 [cytosol]
(Caenorhabditis elegans)
ECT2 [cytosol]
(Bos taurus)
ECT2 [cytosol]
(Canis familiaris)
ECT2 [cytosol]
(Gallus gallus)
ECT2 [cytosol]
(Sus scrofa)
ect2 [cytosol]
(Xenopus tropicalis)
pbl [cytosol]
(Drosophila melanogaster)
Ect2 [cytosol]
(Mus musculus)
Ect2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011510816.1
,
NP_060568.3
,
NP_001245244.1
,
NP_001245245.1
OpenTargets
ENSG00000114346
GeneCards
Q9H8V3
HPA
ENSG00000114346-ECT2
Ensembl
ENSP00000412259
,
ENSP00000415876
,
ENST00000232458
,
ENST00000540509
,
ENSG00000114346
,
ENSP00000232458
,
ENST00000392692
,
ENST00000441497
,
ENST00000417960
,
ENSP00000443160
,
ENSP00000376457
PRO
Q9H8V3
Pharos - Targets
Q9H8V3
PDB
3L46
,
4N40
,
6L30
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H0H5 RACGAP1
1
RACGAP1 [cytosol]
(R-HSA-195122)
0.88
15
UniProt:Q02241 KIF23
3
KIF23 [nucleoplasm]
(R-HSA-156709)
p-S911,S912-KIF23 [nucleoplasm]
(R-HSA-156695)
KIF23 [cytosol]
(R-HSA-1015863)
0.564
2
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.499
3
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.499
3
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