Reactome | ARHGEF9 [cytosol]

ARHGEF9 [cytosol]

Stable Identifier

R-HSA-195067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Collybistin/Pem2, Rho guanine nucleotide exchange factor 9, gephrin

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)
      - NPTN binds GABA A receptors (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)
        
        GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)
        
        ARHGEF9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43307 ARHGEF9

Gene Names

ARHGEF9, ARHDH9, KIAA0424

Chain

chain:1-516

Reference Genes

BioGPS Gene:23229 ARHGEF9

COSMIC (genes):ARHGEF9 ARHGEF9

CTD Gene:23229 ARHGEF9

dbSNP Gene:23229 ARHGEF9

ENSEMBL:ENSG00000131089 ARHGEF9

HGNC:14561 ARHGEF9

KEGG:hsa:23229 ARHGEF9

Monarch:23229 ARHGEF9

NCBI Gene:23229 ARHGEF9

OMIM:300429 ARHGEF9

UCSC:O43307 ARHGEF9

Reference Transcript

Other Identifiers

11721187_a_at

11721188_a_at

11755509_a_at

17111611

203263_PM_s_at

203263_s_at

203264_PM_s_at

203264_s_at

23229

35288_at

4010510

4010512

4010513

4010514

4010515

4010516

4010517

4010518

4010519

4010520

4010522

4010523

4010527

4010528

4010529

4010530

4010531

4010534

4010535

4010536

4010537

4010538

4010539

4010540

4010542

4010543

4010546

4010550

4010551

4010552

4010553

4010554

4010559

4010560

64302_at

64303_g_at

8173217

A_23_P251705

A_24_P254551

GE53176

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0014069

GO:0043226

GO:0045202

GO:0051056

GO:0098772

GO:0098982

GO:0099150

GO:0099572

HMNXSV003005181

Hs.54697.0.S1_3p_a_at

ILMN_1779370

PH_hs_0031243

TC0X001092.hg

g7662107_3p_s_at

Participates

as a member of

as a candidate of

RHOQ GEFs [cytosol] (Homo sapiens)

as a component of

GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)

Inferred To

gxcJ [cytosol] (Dictyostelium discoideum)

gxcM [cytosol] (Dictyostelium discoideum)

gxcE [cytosol] (Dictyostelium discoideum)

Arhgef9 [cytosol] (Mus musculus)

Arhgef9 [cytosol] (Rattus norvegicus)

gxcP [cytosol] (Dictyostelium discoideum)

gxcQ [cytosol] (Dictyostelium discoideum)

RhoGEF3 [cytosol] (Drosophila melanogaster)

gxcI [cytosol] (Dictyostelium discoideum)

ARHGEF9 [cytosol] (Bos taurus)

ARHGEF9 [cytosol] (Gallus gallus)

ARHGEF9 [cytosol] (Sus scrofa)

Homologues of ARHGEF9 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001166951.1, NP_056000.1, NP_001166950.1, XP_016884855.1, XP_016884862.1

ENSEMBL

ENST00000671907, ENST00000623517, ENSP00000253401, ENSP00000485369, ENST00000624843, ENSP00000500829, ENST00000253401, ENSP00000485626

OpenTargets

ENSG00000131089

HPA

ENSG00000131089-ARHGEF9

PRO

O43307

Pharos - Targets

O43307

Orphanet

ARHGEF9

HMDB Protein

HMDBP11460

PDB

2YSQ

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.488	2