Reactome | BCR [cytosol]

BCR [cytosol]

Stable Identifier

R-HSA-195200

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bcr

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11274 BCR

Gene Names

BCR, BCR1, D22S11

Chain

chain:1-1271

Reference Genes

BioGPS Gene:613 BCR

COSMIC (genes):BCR BCR

CTD Gene:613 BCR

dbSNP Gene:613 BCR

ENSEMBL:ENSG00000186716 BCR

HGNC:1014 BCR

KEGG:hsa:613 BCR

Monarch:613 BCR

NCBI Gene:613 BCR

OMIM:151410 BCR

UCSC:P11274 BCR

Reference Transcript

Participates

as a candidate of

as a member of

RAC2 GEFs [cytosol] (Homo sapiens)

Other forms of this molecule

BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

BCR(1-584)-FGFR1(429-822) fusion [cytosol]

Inferred To

RhoGAP1A [cytosol] (Drosophila melanogaster)

Bcr [cytosol] (Mus musculus)

Bcr [cytosol] (Rattus norvegicus)

bcr [cytosol] (Xenopus tropicalis)

BCR [cytosol] (Bos taurus)

BCR [cytosol] (Canis familiaris)

BCR [cytosol] (Gallus gallus)

BCR [cytosol] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2755

OpenTargets

ENSG00000186716

ENSEMBL

ENSP00000303507, ENST00000359540, ENST00000305877, ENSP00000352535, ENSG00000186716

ZINC - Substances

BCR_HUMAN

ZINC target

P11274

PRO

P11274

GlyGen

P11274

PDB

5N6R, 2AIN, 1K1F, 5N7E, 5OC7

IntEnz

2.7.11.1

HPA

ENSG00000186716-BCR

GeneCards

BCR

Pharos - Targets

P11274

Orphanet

BCR

ZINC - Predictions - Purchasable

BCR_HUMAN

HMDB Protein

HMDBP01966

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.928	13
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.595	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.527	3
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.527	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.527	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.483	3

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