Assembly of the destruction complex

Stable Identifier
R-HSA-195251
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The exact composition of the destruction complex is not known. A number of components appear to form a core complex, while others may associate with the complex transiently when a Wnt signal is present (reviewed in Kimelman and Xu, 2006). The core components include Axin, glycogen synthase kinase 3 (GSK-3), Casein kinase 1 (CKI) alpha, beta-catenin, Protein phosphatase 2A (PP2A) and Adenomatous Polyposis Coli (APC). CK1 epsilon, Diversin and PP1 may also be components of the complex.

Literature References
PubMed ID Title Journal Year
10092233 Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

Seeling, JM, Miller, JR, Gil, R, Moon, RT, White, R, Virshup, DM

Science 1999
12554650 Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

Dajani, R, Fraser, E, Roe, SM, Yeo, M, Good, VM, Thompson, V, Dale, TC, Pearl, LH

EMBO J 2003
17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

Major, MB, Camp, ND, Berndt, JD, Yi, X, Goldenberg, SJ, Hubbert, C, Biechele, TL, Gingras, AC, Zheng, N, Maccoss, MJ, Angers, S, Moon, RT

Science 2007
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created