Degradation of beta-catenin by the destruction complex

Stable Identifier
R-HSA-195253
DOI
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).
Literature References
PubMed ID Title Journal Year
17143292 beta-catenin destruction complex: insights and questions from a structural perspective

Kimelman, D, Xu, W

Oncogene 2006
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Orthologous Events
Cross References
BioModels Database
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