Reactome | CSNK1A1 [cytosol]

CSNK1A1 [cytosol]

Stable Identifier

R-HSA-195263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CK1alpha, CSNK1A1

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External Reference Information

External Reference

UniProt:P48729 CSNK1A1

Gene Names

CSNK1A1

Chain

initiator methionine:1, chain:2-337

Reference Genes

BioGPS Gene:1452 CSNK1A1

COSMIC (genes):CSNK1A1 CSNK1A1

CTD Gene:1452 CSNK1A1

dbSNP Gene:1452 CSNK1A1

ENSEMBL:ENSG00000113712 CSNK1A1

HGNC:2451 CSNK1A1

KEGG Gene (Homo sapiens):1452 CSNK1A1

Monarch:1452 CSNK1A1

NCBI Gene:1452 CSNK1A1

OMIM:600505 CSNK1A1

UCSC:P48729 CSNK1A1

Reference Transcript

Other Identifiers

0002570706

11736307_x_at

11736308_s_at

11736309_a_at

11736310_x_at

11748687_s_at

11748688_x_at

11756304_x_at

11762434_s_at

11763318_s_at

1452

206562_s_at

208865_3p_at

208865_at

208866_at

208867_s_at

213086_s_at

213860_x_at

2880885

2880886

2880902

2880906

2880907

2880908

2880909

2880910

2880911

2880912

2880913

2880914

2880915

2880923

2880925

2880927

2880929

2880931

2880933

2880934

2880935

2880936

2880937

2880938

2880939

2880940

2880941

2880942

2880943

2880944

2880945

2880979

2880999

3509988

3618298

3618307

40184_at

73359_at

8115022

81830_r_at

A_24_P183292

A_24_P251899

GE512141

GE57745

GE85967

GO:0000166

GO:0000775

GO:0000776

GO:0000777

GO:0000902

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005847

GO:0005856

GO:0005929

GO:0006464

GO:0006468

GO:0007010

GO:0007030

GO:0007049

GO:0007165

GO:0007166

GO:0007267

GO:0008150

GO:0009056

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0022607

GO:0030877

GO:0032436

GO:0032991

GO:0036064

GO:0042995

GO:0043167

GO:0043226

GO:0045095

GO:0045104

GO:0048856

GO:0051301

GO:0065003

GO:0090090

GO:1904424

GO:1904885

GO:1904886

GO:1990904

Hs.144477.0.S2_3p_s_at

Hs.144477.0.S2_3p_x_at

Hs.144477.0.S3_3p_at

Hs.144477.0.S3_3p_x_at

Hs.84264.3.A1_3p_s_at

ILMN_1775058

ILMN_1785988

ILMN_2364174

L37042_at

PH_hs_0029731

TC05001924.hg

g4503088_3p_a_at

g4503088_3p_x_at

g7770258_RC_3p_a_at

Participant Of

input

hasComponent

hasMember

CK1alpha (GSK3) [cytosol]

output

Beta-catenin is released from the destruction complex

Other forms of this molecule

CSNK1A1 [cilium]

Inferred To

Csnk1a1 [cytosol] (Mus musculus)

Csnk1a1 [cytosol] (Rattus norvegicus)

CKIalpha like [cytosol] (Drosophila melanogaster)

csnk1a1 [cytosol] (Danio rerio)

Dmel\CG2577 [cytosol] (Drosophila melanogaster)

Homologues of CSNK1A1 [cytosol] (Bos taurus)

Homologues of CSNK1A1 [cytosol] (Canis familiaris)

Homologues of CSNK1A1 [cytosol] (Drosophila melanogaster)

zeb2 [cytosol] (Xenopus tropicalis)

LOC100138998 [cytosol] (Bos taurus)

Ghost homologue of CSNK1A1 [cytosol] (Sus scrofa)

LOC613515 [cytosol] (Bos taurus)

CkIalpha [cytosol] (Drosophila melanogaster)

CSNK1A1 [cytosol] (Bos taurus)

CSNK1A1 [cytosol] (Canis familiaris)

CSNK1A1 [cytosol] (Dictyostelium discoideum)

CSNK1A1 [cytosol] (Gallus gallus)

Dmel\CG7094 [cytosol] (Drosophila melanogaster)

kin-19 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001258670.1, NP_001258671.1, NP_001020276.1, NP_001883.4

ZINC - World Drugs

KC1A_HUMAN

OpenTargets

ENSG00000113712

ZINC - FDA approved

KC1A_HUMAN

ZINC - Substances

KC1A_HUMAN

ZINC - Biogenic

KC1A_HUMAN

ZINC target

P48729

PRO

P48729

PDB

5FQD, 6GZD

ZINC - Investigational

KC1A_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000113712-CSNK1A1

GeneCards

P48729

Ensembl

ENSP00000367074, ENSG00000113712, ENST00000657001, ENSP00000261798, ENSP00000499757, ENST00000261798, ENST00000377843

ZINC - Predictions - Purchasable

KC1A_HUMAN

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZRV2 FA83H			0.752	10
UniProt:A6ND36 FA83G			0.722	12
UniProt:Q5T0W9 FA83B			0.664	7
UniProt:Q9H4H8 FA83D			0.649	5
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.643	4
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.641	3
UniProt:Q9BQN1 FA83C			0.61	6
UniProt:Q13546 RIPK1	14	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.602	5
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.589	2
UniProt:Q63629 Q63629			0.544	2
UniProt:Q2M2I3 FA83E			0.537	6
UniProt:Q8NEG4 FA83F			0.537	7
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.527	2
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	7
UniProt:Q9BXL7 CARD11	5	CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) p-S552,S645-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.499	5
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.488	2
UniProt:P09429 HMGB1	5	HMGB1 [extracellular region] (R-HSA-879382) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.488	2
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.488	3
UniProt:Q96A00 PPP1R14A	2	p-T38-PPP1R14A [cytosol] (R-HSA-5671764) PPP1R14A [cytosol] (R-HSA-5671761)	0.488	2