Reactome | CSNK1A1 [cytosol]

CSNK1A1 [cytosol]

Stable Identifier

R-HSA-195263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CK1alpha, CSNK1A1

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External Reference Information

External Reference

UniProt:P48729 CSNK1A1

Gene Names

CSNK1A1

Chain

initiator methionine:1, chain:2-337

Reference Genes

BioGPS Gene:1452 CSNK1A1

COSMIC (genes):CSNK1A1 CSNK1A1

CTD Gene:1452 CSNK1A1

dbSNP Gene:1452 CSNK1A1

ENSEMBL:ENSG00000113712 CSNK1A1

ENSEMBL:ENSG00000113712.19 CSNK1A1

HGNC:2451 CSNK1A1

KEGG Gene (Homo sapiens):1452 CSNK1A1

Monarch:1452 CSNK1A1

NCBI Gene:1452 CSNK1A1

OMIM:600505 CSNK1A1

UCSC:P48729 CSNK1A1

Reference Transcript

Other Identifiers

11736307_x_at

11736308_s_at

11736309_a_at

11736310_x_at

11748687_s_at

11748688_x_at

11756304_x_at

11762434_s_at

11763318_s_at

1452

206562_PM_s_at

206562_s_at

208865_3p_at

208865_PM_at

208865_at

208866_PM_at

208866_at

208867_PM_s_at

208867_s_at

213086_PM_s_at

213086_s_at

213860_PM_x_at

213860_x_at

2880885

2880886

2880902

2880906

2880907

2880908

2880909

2880910

2880911

2880912

2880913

2880914

2880915

2880923

2880925

2880927

2880929

2880931

2880933

2880934

2880935

2880936

2880937

2880938

2880939

2880940

2880941

2880942

2880943

2880944

2880945

2880979

2880999

3509988

3618298

3618307

40184_at

73359_at

8115022

81830_r_at

A_24_P183292

A_24_P251899

GE512141

GE57745

GE85967

GO:0000166

GO:0000775

GO:0000776

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005847

GO:0005856

GO:0005929

GO:0006468

GO:0007010

GO:0007030

GO:0007049

GO:0007165

GO:0007166

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0019082

GO:0023052

GO:0030163

GO:0030877

GO:0032436

GO:0036064

GO:0036211

GO:0042995

GO:0043161

GO:0043226

GO:0045095

GO:0045104

GO:0051301

GO:0065003

GO:0090090

GO:0106310

GO:0140096

GO:1900226

GO:1904424

HMNXSV003031868

HMNXSV003052993

Hs.144477.0.S2_3p_s_at

Hs.144477.0.S2_3p_x_at

Hs.144477.0.S3_3p_at

Hs.144477.0.S3_3p_x_at

Hs.84264.3.A1_3p_s_at

ILMN_1775058

ILMN_1785988

ILMN_2364174

L37042_at

PH_hs_0029731

TC05001924.hg

g4503088_3p_a_at

g4503088_3p_x_at

g7770258_RC_3p_a_at

p13448

p13449

Participates

as an input of

as a component of

as a member of

CK1alpha (GSK3) [cytosol] (Homo sapiens)

as an output of

Beta-catenin is released from the destruction complex (Homo sapiens)

Other forms of this molecule

CSNK1A1 [cilium]

Inferred To

Homologues of CSNK1A1 [cytosol] (Bos taurus)

Homologues of CSNK1A1 [cytosol] (Drosophila melanogaster)

CSNK1A1 [cytosol] (Bos taurus)

CSNK1A1 [cytosol] (Caenorhabditis elegans)

CSNK1A1 [cytosol] (Canis familiaris)

CSNK1A1 [cytosol] (Danio rerio)

CSNK1A1 [cytosol] (Drosophila melanogaster)

CSNK1A1 [cytosol] (Gallus gallus)

CSNK1A1 [cytosol] (Mus musculus)

CSNK1A1 [cytosol] (Rattus norvegicus)

CSNK1A1 [cytosol] (Sus scrofa)

CSNK1A1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001258671.1, NP_001020276.1, NP_001258670.1, NP_001883.4

ZINC - World Drugs

KC1A_HUMAN

Guide to Pharmacology - Targets

1995

OpenTargets

ENSG00000113712

ZINC - FDA approved

KC1A_HUMAN

ZINC - Substances

KC1A_HUMAN

ZINC target

P48729

ZINC - Biogenic

KC1A_HUMAN

PRO

P48729

PDB

6GZD, 7WTT, 5FQD

ZINC - Investigational

KC1A_HUMAN

GeneCards

P48729

HPA

ENSG00000113712-CSNK1A1

Ensembl

ENSP00000261798, ENSP00000499757, ENST00000261798, ENST00000377843, ENSP00000367074, ENSG00000113712, ENST00000657001

Pharos - Targets

P48729

ZINC - Predictions - Purchasable

KC1A_HUMAN

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZRV2 FA83H			0.805	11
UniProt:A6ND36 FA83G			0.783	13
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.739	8
UniProt:Q9H4H8 FA83D			0.649	5
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.643	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.643	4
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.641	3
UniProt:Q9BQN1 FA83C			0.61	6
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.602	5
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.589	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:Q63629 Q63629			0.544	2
UniProt:Q8NEG4 FA83F			0.537	7
UniProt:Q2M2I3 FA83E			0.537	6
UniProt:Q5T7W0 ZN618			0.527	2
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.527	2
UniProt:Q9Y343 SNX24			0.527	2
UniProt:Q9UK59 DBR1			0.527	2
UniProt:Q9H3U1 UN45A			0.527	2
UniProt:Q7L775 EPMIP			0.527	2
UniProt:Q70CQ2 USP34	1	USP34 [cytosol] (R-HSA-2130272)	0.527	2
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	4
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.527	2
UniProt:P48730 CSNK1D	3	CSNK1D [nucleoplasm] (R-HSA-421305) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [cytosol] (R-HSA-380315)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.499	5
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	7
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221)	0.488	2
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.488	2
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.488	3
UniProt:Q96A00 PPP1R14A	2	PPP1R14A [cytosol] (R-HSA-5671761) p-T38-PPP1R14A [cytosol] (R-HSA-5671764)	0.488	2