Reactome | CSNK1A1 [cytosol]

CSNK1A1 [cytosol]

Stable Identifier

R-HSA-195263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CK1alpha, CSNK1A1

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P48729 CSNK1A1

Gene Names

CSNK1A1

Chain

initiator methionine:1, chain:2-337

Reference Genes

BioGPS Gene:1452 CSNK1A1

COSMIC (genes):CSNK1A1 CSNK1A1

CTD Gene:1452 CSNK1A1

dbSNP Gene:1452 CSNK1A1

ENSEMBL:ENSG00000113712 CSNK1A1

HGNC:2451 CSNK1A1

KEGG Gene (Homo sapiens):1452 CSNK1A1

Monarch:1452 CSNK1A1

NCBI Gene:1452 CSNK1A1

OMIM:600505 CSNK1A1

UCSC:P48729 CSNK1A1

Reference Transcript

Other Identifiers

0002570706

11736307_x_at

11736308_s_at

11736309_a_at

11736310_x_at

11748687_s_at

11748688_x_at

11756304_x_at

11762434_s_at

11763318_s_at

1452

16680

206562_s_at

208865_3p_at

208865_at

208866_at

208867_s_at

213086_s_at

213860_x_at

2880885

2880886

2880902

2880906

2880907

2880908

2880909

2880910

2880911

2880912

2880913

2880914

2880915

2880923

2880925

2880927

2880929

2880931

2880933

2880934

2880935

2880936

2880937

2880938

2880939

2880940

2880941

2880942

2880943

2880944

2880945

2880979

2880999

3509988

3618298

3618307

40184_at

51334

5FQD

6GZD

73359_at

8115022

81830_r_at

A_24_P183292

A_24_P251899

AAC41760

AAG17246

AAH08717

AAV38632

AAV38633

AAY84562

AC021078

AF218004

AK294942

BAG58018

BC008717

BT019829

BT019830

CAA56710

CAB016680

CAG47002

CCDS47303

CCDS47304

CH471062

CR542206

CSNK1A1

CSNK1A1-201

CSNK1A1-202

CSNK1A1-207

D6REM4

D6RGE5

DQ082865

E5RG27

E7ETM0

EAW61767

EAW61769

EAW61773

EAW61774

EAW61776

ENSG00000113712

ENSP00000261798

ENSP00000367074

ENSP00000421689

ENST00000261798

ENST00000377843

ENST00000377843.6

ENST00000515768

ENST00000515768.5

EntrezGene:1452

EntrezGene:CSNK1A1

g4503088_3p_a_at

g4503088_3p_x_at

g7770258_RC_3p_a_at

GE512141

GE57745

GE85967

GO:0000166

GO:0000775

GO:0000776

GO:0000777

GO:0000902

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005847

GO:0005856

GO:0005929

GO:0006464

GO:0006468

GO:0007010

GO:0007030

GO:0007049

GO:0007165

GO:0007166

GO:0007267

GO:0008150

GO:0009056

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0022607

GO:0030877

GO:0032436

GO:0032991

GO:0036064

GO:0042995

GO:0043167

GO:0043226

GO:0045095

GO:0045104

GO:0048856

GO:0051301

GO:0065003

GO:0090090

GO:1904424

GO:1904885

GO:1904886

GO:1990904

HGNC:2451

HPA051334

Hs.144477.0.S2_3p_s_at

Hs.144477.0.S2_3p_x_at

Hs.144477.0.S3_3p_at

Hs.144477.0.S3_3p_x_at

Hs.84264.3.A1_3p_s_at

ILMN_1775058

ILMN_1785988

ILMN_2364174

IPR000719

IPR008271

IPR011009

IPR017441

L37042

L37042_at

MIM:600505

NM_001025105

NM_001892

NP_001020276

NP_001883

PF00069

PH_hs_0029731

SM00220

TC05001924.hg

UPI000000412B

UPI0000171134

UPI000053FD0F

X80693

Participant Of

input

hasComponent

hasMember

CK1alpha (GSK3) [cytosol]

output

Beta-catenin is released from the destruction complex

Other forms of this molecule

CSNK1A1 [cilium]

Inferred To

CSNK1A1 [cytosol] (Bos taurus)

CSNK1A1 [cytosol] (Caenorhabditis elegans)

CSNK1A1 [cytosol] (Canis familiaris)

CSNK1A1 [cytosol] (Danio rerio)

CSNK1A1 [cytosol] (Drosophila melanogaster)

CSNK1A1 [cytosol] (Gallus gallus)

CSNK1A1 [cytosol] (Mus musculus)

CSNK1A1 [cytosol] (Rattus norvegicus)

CSNK1A1 [cytosol] (Sus scrofa)

CSNK1A1 [cytosol] (Xenopus tropicalis)

Cross References

ZINC - Investigational

KC1A_HUMAN

RefSeq

NP_001258670.1, NP_001258671.1, NP_001020276.1, NP_001883.4

ZINC - World Drugs

KC1A_HUMAN

OpenTargets

ENSG00000113712

ZINC - FDA approved

KC1A_HUMAN

ZINC - Substances

KC1A_HUMAN

GeneCards

P48729

ZINC target

P48729

ZINC - Biogenic

KC1A_HUMAN

PRO

P48729

ZINC - Predictions - Purchasable

KC1A_HUMAN

PDB

5FQD, 6GZD

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512)	0.643	4
UniProt:Q96SW2 CRBN			0.641	3
UniProt:Q13546 RIPK1	9	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) p-S-RIPK1 [cytosol] (R-HSA-5218872) RIPK1 [cytosol] (R-HSA-168651) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021)	0.602	5
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.589	2
UniProt:Q63629 Q63629			0.544	2
UniProt:Q6ZRV2 FA83H			0.527	2
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.527	2
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	7
UniProt:Q9BXL7 CARD11	5	CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) p-S552,S645-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.499	5
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.488	2
UniProt:P18754 RCC1	1	RCC1 [nucleoplasm] (R-HSA-180690)	0.488	3
UniProt:Q96A00 PPP1R14A	2	PPP1R14A [cytosol] (R-HSA-5671761) p-T38-PPP1R14A [cytosol] (R-HSA-5671764)	0.488	2
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382)	0.488	2