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CSNK1A1 [cytosol]
Stable Identifier
R-HSA-195263
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CK1alpha, CSNK1A1
Icon
Locations in the PathwayBrowser for interactor UniProt:P09429 HMGB1
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
Signaling by AXIN mutants (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
CK1 phosphorylates p-GLI2 (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
CK1 phosphorylates p-GLI3 (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CSNK1A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48729 CSNK1A1
Gene Names
CSNK1A1
Chain
initiator methionine:, chain:2-337
Reference Genes
BioGPS Gene:1452 CSNK1A1
COSMIC (genes):CSNK1A1 CSNK1A1
CTD Gene:1452 CSNK1A1
dbSNP Gene:1452 CSNK1A1
ENSEMBL:ENSG00000113712 CSNK1A1
ENSEMBL_homo_sapiens_GENE:ENSG00000113712.19 CSNK1A1
HGNC:2451 CSNK1A1
KEGG Gene (Homo sapiens):1452 CSNK1A1
Monarch:1452 CSNK1A1
NCBI Gene:1452 CSNK1A1
OMIM:600505 CSNK1A1
UCSC:P48729 CSNK1A1
Reference Transcript
RefSeq:NM_001271741.1 CSNK1A1
RefSeq:NM_001025105.2 CSNK1A1
RefSeq:NM_001892.5 CSNK1A1
RefSeq:NM_001271742.1 CSNK1A1
Other Identifiers
11736307_x_at
11736308_s_at
11736309_a_at
11736310_x_at
11748687_s_at
11748688_x_at
11756304_x_at
11762434_s_at
11763318_s_at
1452
206562_PM_s_at
206562_s_at
208865_3p_at
208865_PM_at
208865_at
208866_PM_at
208866_at
208867_PM_s_at
208867_s_at
213086_PM_s_at
213086_s_at
213860_PM_x_at
213860_x_at
2880885
2880886
2880902
2880906
2880907
2880908
2880909
2880910
2880911
2880912
2880913
2880914
2880915
2880923
2880925
2880927
2880929
2880931
2880933
2880934
2880935
2880936
2880937
2880938
2880939
2880940
2880941
2880942
2880943
2880944
2880945
2880979
2880999
3509988
3618298
3618307
40184_at
73359_at
8115022
81830_r_at
A_24_P183292
A_24_P251899
GE512141
GE57745
GE85967
GO:0000166
GO:0000775
GO:0000776
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005847
GO:0005856
GO:0005929
GO:0006468
GO:0007010
GO:0007030
GO:0007049
GO:0007165
GO:0007166
GO:0016020
GO:0016055
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0019082
GO:0023052
GO:0030163
GO:0030877
GO:0031670
GO:0032436
GO:0035025
GO:0036064
GO:0036211
GO:0042995
GO:0043161
GO:0043226
GO:0045095
GO:0045104
GO:0051301
GO:0065003
GO:0090090
GO:0106310
GO:0140096
GO:1900226
GO:1904263
HMNXSV003031868
HMNXSV003052993
Hs.144477.0.S2_3p_s_at
Hs.144477.0.S2_3p_x_at
Hs.144477.0.S3_3p_at
Hs.144477.0.S3_3p_x_at
Hs.84264.3.A1_3p_s_at
ILMN_1775058
ILMN_1785988
ILMN_2364174
L37042_at
PH_hs_0029731
TC05001924.hg
g4503088_3p_a_at
g4503088_3p_x_at
g7770258_RC_3p_a_at
p13448
p13449
Participates
as an input of
AXIN mutants destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
as a component of
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
as a member of
CK1alpha (GSK3) [cytosol] (Homo sapiens)
as an output of
Beta-catenin is released from the destruction complex (Homo sapiens)
Other forms of this molecule
CSNK1A1 [cilium]
Inferred To
CSNK1A1 [cytosol]
(Bos taurus)
CSNK1A1 [cytosol]
(Caenorhabditis elegans)
CSNK1A1 [cytosol]
(Canis familiaris)
CSNK1A1 [cytosol]
(Danio rerio)
CSNK1A1 [cytosol]
(Drosophila melanogaster)
CSNK1A1 [cytosol]
(Gallus gallus)
CSNK1A1 [cytosol]
(Mus musculus)
CSNK1A1 [cytosol]
(Rattus norvegicus)
CSNK1A1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001258671.1
,
NP_001258670.1
,
NP_001883.4
,
NP_001020276.1
ZINC - World Drugs
KC1A_HUMAN
Guide to Pharmacology - Targets
1995
OpenTargets
ENSG00000113712
ZINC - FDA approved
KC1A_HUMAN
ZINC - Substances
KC1A_HUMAN
ZINC target
P48729
ZINC - Biogenic
KC1A_HUMAN
PRO
P48729
PDB
6GZD
,
5FQD
,
8G66
,
7WTT
ZINC - Investigational
KC1A_HUMAN
HPA
ENSG00000113712-CSNK1A1
GeneCards
P48729
Ensembl
ENSG00000113712
,
ENSP00000367074
,
ENSP00000499757
,
ENST00000657001
,
ENSP00000261798
,
ENST00000377843
,
ENST00000261798
Pharos - Targets
P48729
ZINC - Predictions - Purchasable
KC1A_HUMAN
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZRV2 FA83H
0.885
13
UniProt:A6ND36 FA83G
0.87
16
UniProt:Q5T0W9 FAM83B
1
FAM83B [cytosol]
(R-HSA-9715184)
0.796
9
UniProt:Q9H4H8 FAM83D
1
FAM83D [cytosol]
(R-HSA-9852722)
0.787
7
UniProt:O15151 MDM4
5
PolyUb-MDM4 [nucleoplasm]
(R-HSA-6782502)
p-S403-MDM4 [nucleoplasm]
(R-HSA-349461)
p-S346,S367,S403-MDM4 [nucleoplasm]
(R-HSA-349441)
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
(R-HSA-6804938)
MDM4 [nucleoplasm]
(R-HSA-349430)
0.758
5
UniProt:O75330 HMMR
2
HMMR [plasma membrane]
(R-HSA-2160885)
HMMR [cytosol]
(R-HSA-8861624)
0.725
4
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.725
4
UniProt:Q9UJF2 RASAL2
1
RASAL2 [cytosol]
(R-HSA-5658224)
0.725
4
UniProt:Q9Y343 SNX24
0.725
4
UniProt:Q70CQ2 USP34
1
USP34 [cytosol]
(R-HSA-2130272)
0.725
4
UniProt:Q5T7W0 ZN618
0.643
3
UniProt:Q14C86 GAPVD1
1
GAPVD1 [cytosol]
(R-HSA-8871123)
0.643
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.643
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.643
4
UniProt:Q9UK59 DBR1
0.643
3
UniProt:Q9H3U1 UN45A
0.643
3
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
SEC13 [cytosol]
(R-HSA-203981)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
0.643
3
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.641
3
UniProt:Q9BQN1 FA83C
0.61
6
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.602
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q63629 Q63629
0.544
2
UniProt:Q8NEG4 FA83F
0.537
7
UniProt:Q2M2I3 FA83E
0.537
6
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q7Z5H3 ARHGAP22
1
ARHGAP22 [cytosol]
(R-HSA-200762)
0.527
2
UniProt:Q9HCK1 ZDBF2
0.527
2
UniProt:Q7L775 EPMIP
0.527
2
UniProt:P49917 LIG4
1
LIG4 [nucleoplasm]
(R-HSA-53791)
0.527
2
UniProt:O14867 BACH1
5
BACH1 [nucleoplasm]
(R-HSA-9707688)
BACH1 [cytosol]
(R-HSA-9708429)
PolyUb-BACH1 [nucleoplasm]
(R-HSA-9708486)
p-Y483 BACH1 [nucleoplasm]
(R-HSA-9762202)
p-Y483 BACH1 [cytosol]
(R-HSA-9762206)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
4
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.527
2
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.527
2
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.524
3
UniProt:Q9BXL7 CARD11
5
p-S559,S644,S652-CARD11 [plasma membrane]
(R-HSA-1168564)
CARD11 [plasma membrane]
(R-HSA-2685592)
p-S559,S652-CARD11 [cytosol]
(R-HSA-2685625)
CARD11 [cytosol]
(R-HSA-202161)
p-S552-CARD11 [cytosol]
(R-HSA-202438)
0.499
5
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.499
7
UniProt:P26583 HMGB2
1
HMGB2 [nucleoplasm]
(R-HSA-266211)
0.488
2
UniProt:Q96A00 PPP1R14A
2
p-T38-PPP1R14A [cytosol]
(R-HSA-5671764)
PPP1R14A [cytosol]
(R-HSA-5671761)
0.488
2
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
0.488
2
UniProt:P18754 RCC1
2
RCC1 [nucleoplasm]
(R-HSA-180690)
RCC1 [chromosome]
(R-HSA-9668547)
0.488
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.483
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
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