Phosphorylation of APC component of the destruction complex

Stable Identifier
R-HSA-195275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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APC is phosphorylated on the 20 aa repeats by CK1 and potentially GSK-3. This significantly increases the binding affinity of the APC 20 aa repeats for beta-catenin, causing one of them to bind b-catenin in the same region as beta-catenin binds Axin, thus displacing beta-catenin from Axin ( Step 5 above) (Reviewed in Kimelman, 2006).

Literature References
PubMed ID Title Journal Year
16753179 The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

Liu, J, Xing, Y, Hinds, TR, Zheng, J, Xu, W

J Mol Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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