Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3

Stable Identifier
R-HSA-195300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
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Beta-catenin is then phosphorylated at Ser33. Phosphorylated S37 and S33 together with neighboring residues constitute the recognition motif for beta-TrCP.

Literature References
PubMed ID Title Journal Year
11955436 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Liu, C, Li, Y, Semenov, M, Han, C, Baeg, GH, Tan, Y, Zhang, Z, Lin, X, He, X

Cell 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Physical Entity
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
This event is regulated
Negatively by
Orthologous Events
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Danio rerio)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)
Authored
Kimelman, D  (2007-04-03)
Reviewed
Pagano, M  (2007-04-27)
Created
Matthews, L  (2007-04-03)
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