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RAC2 [cytosol]
Stable Identifier
R-HSA-195343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rac2
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
VAV1 Rho/Rac effectors:GDP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
VAV1 Rho/Rac effectors:GTP [cytosol] (Homo sapiens)
VAV1 effectors [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GDIs block activation of RAC2 (Homo sapiens)
ARHGDIA:RAC2:GDP [cytosol] (Homo sapiens)
RAC2:GDP [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
ppDVL recruits RAC (Homo sapiens)
RAC:GTP [cytosol] (Homo sapiens)
RAC [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
pp-DVL:RAC:GTP [plasma membrane] (Homo sapiens)
RAC:GTP [cytosol] (Homo sapiens)
RAC [cytosol] (Homo sapiens)
RAC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15153 RAC2
Gene Names
RAC2
Chain
chain:1-189, propeptide:190-192
Reference Genes
BioGPS Gene:5880 RAC2
COSMIC (genes):RAC2 RAC2
CTD Gene:5880 RAC2
dbSNP Gene:5880 RAC2
ENSEMBL:ENSG00000128340 RAC2
ENSEMBL_homo_sapiens_GENE:ENSG00000128340.16 RAC2
HGNC:9802 RAC2
KEGG Gene (Homo sapiens):5880 RAC2
Monarch:5880 RAC2
NCBI Gene:5880 RAC2
OMIM:602049 RAC2
UCSC:P15153 RAC2
Reference Transcript
RefSeq:NM_002872.4 RAC2
Other Identifiers
11744263_s_at
16934749
207419_3p_s_at
207419_PM_s_at
207419_s_at
213603_PM_s_at
213603_s_at
2989055
32736_at
32737_at
3960062
3960063
3960064
3960065
3960066
3960067
3960069
3960071
3960079
3960080
3960081
5880
8075910
A_23_P218770
A_23_P218774
A_24_P228717
GE80267
GE81848
GO:0000166
GO:0002376
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006886
GO:0006935
GO:0007005
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0007186
GO:0007264
GO:0008283
GO:0010310
GO:0010592
GO:0010810
GO:0016020
GO:0016192
GO:0016787
GO:0019887
GO:0023052
GO:0030027
GO:0030031
GO:0030036
GO:0030154
GO:0030334
GO:0030670
GO:0031410
GO:0042129
GO:0043020
GO:0043131
GO:0043226
GO:0043304
GO:0045453
GO:0045730
GO:0048856
GO:0048870
GO:0060263
GO:0060753
GO:0070062
GO:0070662
GO:0070668
GO:0071593
GO:0090023
GO:0098772
GO:1902622
GO:1903955
HMNXSV003032615
Hs.301175.1.S1_3p_s_at
ILMN_1709795
M64595_at
PH_hs_0015519
TC22000725.hg
Participates
as a component of
RAC2:GDP [cytosol] (Homo sapiens)
as a member of
VAV1 effectors [cytosol] (Homo sapiens)
as a candidate of
RAC [cytosol] (Homo sapiens)
Other forms of this molecule
RAC2 [endoplasmic reticulum membrane]
RAC2 [mitochondrial outer membrane]
RAC2 [phagocytic vesicle membrane]
RAC2 [plasma membrane]
Inferred To
RAC2 [cytosol]
(Bos taurus)
RAC2 [cytosol]
(Caenorhabditis elegans)
RAC2 [cytosol]
(Canis familiaris)
RAC2 [cytosol]
(Dictyostelium discoideum)
RAC2 [cytosol]
(Drosophila melanogaster)
RAC2 [cytosol]
(Gallus gallus)
RAC2 [cytosol]
(Mus musculus)
RAC2 [cytosol]
(Sus scrofa)
racQ [cytosol]
(Dictyostelium discoideum)
rac2 [cytosol]
(Danio rerio)
rac2 [cytosol]
(Xenopus tropicalis)
racP [cytosol]
(Dictyostelium discoideum)
Homologues of RAC2 [cytosol]
(Caenorhabditis elegans)
Homologues of RAC2 [cytosol]
(Dictyostelium discoideum)
Homologues of RAC2 [cytosol]
(Drosophila melanogaster)
RAC1 [cytosol]
(Caenorhabditis elegans)
RAC1 [cytosol]
(Dictyostelium discoideum)
RAC1_DROME [cytosol]
(Drosophila melanogaster)
Rac2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_002863.1
OpenTargets
ENSG00000128340
HPA
ENSG00000128340-RAC2
GeneCards
P15153
Ensembl
ENSG00000128340
,
ENSP00000249071
,
ENST00000249071
PRO
P15153
Pharos - Targets
P15153
Orphanet
18485
PDB
2W2V
,
2W2T
,
1DS6
,
2W2X
HMDB Protein
HMDBP01788
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.556
3
UniProt:P52306 RAP1GDS1
1
RAP1GDS1 [mitochondrial outer membrane]
(R-HSA-9693756)
0.527
2
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