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VEGFR2 [plasma membrane]
Stable Identifier
R-HSA-195382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
KDR, Kinase insert domain receptor
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14114 LRP8
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Endorepellin binds KDR (VEGFR2) (Homo sapiens)
VEGFR2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
Neurophilin interactions with VEGF and VEGFR (Homo sapiens)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)
VEGFR2 [plasma membrane] (Homo sapiens)
VEGF ligand-receptor interactions (Homo sapiens)
VEGF binds to VEGFR leading to receptor dimerization (Homo sapiens)
VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)
VEGFR2 [plasma membrane] (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)
VEGFR2 [plasma membrane] (Homo sapiens)
VEGFR2 autophosphorylates (Homo sapiens)
VEGFR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35968 KDR
Gene Names
KDR, FLK1, VEGFR2
Chain
signal peptide:1-19, chain:20-1356
Reference Genes
BioGPS Gene:3791 KDR
COSMIC (genes):KDR KDR
CTD Gene:3791 KDR
dbSNP Gene:3791 KDR
ENSEMBL:ENSG00000128052 KDR
HGNC:6307 KDR
KEGG:hsa:3791 KDR
Monarch:3791 KDR
NCBI Gene:3791 KDR
OMIM:191306 KDR
UCSC:P35968 KDR
Reference Transcript
RefSeq:NM_002253.2 KDR
Other Identifiers
11739315_at
11739316_at
16976029
1954_at
203934_PM_at
203934_at
2769811
2769812
2769813
2769814
2769815
2769816
2769817
2769818
2769819
2769820
2769821
2769822
2769824
2769825
2769826
2769827
2769828
2769831
2769832
2769833
2769834
2769835
2769837
2769838
2769839
2769840
2769842
2769845
2769848
2769849
2769850
2769851
2769852
2769853
2769856
2769857
2769860
2769861
2769862
2769863
3791
690_s_at
8100393
A_23_P58419
A_24_P71973
GE54268
GO:0001525
GO:0001541
GO:0001569
GO:0001570
GO:0001934
GO:0001938
GO:0001945
GO:0002042
GO:0002053
GO:0002070
GO:0003157
GO:0003158
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005021
GO:0005178
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005794
GO:0005886
GO:0006468
GO:0007169
GO:0008284
GO:0008360
GO:0009897
GO:0009986
GO:0010463
GO:0010595
GO:0010629
GO:0015026
GO:0016020
GO:0016239
GO:0016477
GO:0016740
GO:0018108
GO:0019838
GO:0030054
GO:0030097
GO:0030154
GO:0030324
GO:0030335
GO:0030513
GO:0031401
GO:0031410
GO:0035162
GO:0035924
GO:0036324
GO:0038083
GO:0038084
GO:0038085
GO:0042802
GO:0043129
GO:0043226
GO:0043235
GO:0043408
GO:0043410
GO:0043524
GO:0043536
GO:0045121
GO:0045165
GO:0045296
GO:0045446
GO:0045766
GO:0045937
GO:0046777
GO:0048010
GO:0048286
GO:0048597
GO:0048754
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050927
GO:0051770
GO:0051879
GO:0051894
GO:0051897
GO:0051901
GO:0055074
GO:0060089
GO:0060837
GO:0061042
GO:0070161
GO:0070374
GO:0071526
GO:0071944
GO:0072089
GO:0090050
GO:0090141
GO:0097443
GO:0140096
GO:1901532
GO:1903010
GO:1904881
GO:2000352
GO:2000648
GO:2001028
GO:2001214
HMNXSV003003815
ILMN_1686405
L04947_at
PH_hs_0001165
TC04001208.hg
g11321596_3p_at
Participates
as a component of
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
HSPG2(3687-4391):KDR [plasma membrane] (Homo sapiens)
VEGFR2 dimer [plasma membrane] (Homo sapiens)
VEGFA-165 dimer:VEGFR2 [plasma membrane] (Homo sapiens)
as an input of
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)
Endorepellin binds KDR (VEGFR2) (Homo sapiens)
VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)
VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)
VEGFR2 autophosphorylates (Homo sapiens)
Other forms of this molecule
p-6Y-VEGFR2 [plasma membrane]
p-Y801,Y1054,Y1175-KDR [plasma membrane]
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
Inferred To
kin-36 [plasma membrane]
(Caenorhabditis elegans)
Homologues of VEGFR2 [plasma membrane]
(Caenorhabditis elegans)
VEGFR2 [plasma membrane]
(Bos taurus)
VEGFR2 [plasma membrane]
(Caenorhabditis elegans)
VEGFR2 [plasma membrane]
(Canis familiaris)
VEGFR2 [plasma membrane]
(Danio rerio)
VEGFR2 [plasma membrane]
(Drosophila melanogaster)
VEGFR2 [plasma membrane]
(Gallus gallus)
VEGFR2 [plasma membrane]
(Mus musculus)
VEGFR2 [plasma membrane]
(Rattus norvegicus)
VEGFR2 [plasma membrane]
(Sus scrofa)
VEGFR2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002244.1
ZINC - World Drugs
VGFR2_HUMAN
Guide to Pharmacology - Targets
1813
OpenTargets
ENSG00000128052
ENSEMBL
ENST00000263923
,
ENSP00000263923
ZINC - FDA approved
VGFR2_HUMAN
ZINC - Substances
VGFR2_HUMAN
ZINC - Biogenic
VGFR2_HUMAN
ZINC target
P35968
PRO
P35968
GlyGen
P35968
PDB
4AGC
,
4AGD
,
3KVQ
,
3CJG
,
2P2I
,
6GQQ
,
3CJF
,
3B8R
,
2MEU
,
3U6J
,
3CP9
,
2RL5
,
4ASE
,
4AG8
,
6XVK
,
3VHE
,
2QU5
,
3VNT
,
3S35
,
3WZD
,
1Y6B
,
2M59
,
5EW3
,
3V6B
,
3VO3
,
3S36
,
3VID
,
1VR2
,
2QU6
,
2X1W
,
3EFL
,
3DTW
,
2P2H
,
6GQP
,
2X1X
,
3VHK
,
5OYJ
,
3EWH
,
3B8Q
,
2MET
,
4ASD
,
1YWN
,
6XVJ
,
3WZE
,
3CPB
,
3BE2
,
1Y6A
,
6GQO
,
3C7Q
,
3S37
,
3V2A
,
2OH4
,
3CPC
,
2XIR
ZINC - Investigational
VGFR2_HUMAN
ZINC - Metabolites
VGFR2_HUMAN
HPA
ENSG00000128052-KDR
Pharos - Targets
P35968
Orphanet
KDR
ZINC - Predictions - Purchasable
VGFR2_HUMAN
HMDB Protein
HMDBP01272
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15692-4 VEGFA
1
VEGFA-165 [extracellular region]
(R-HSA-4420127)
0.847
8
UniProt:P15692 VEGFA
2
VEGFA [platelet alpha granule lumen]
(R-HSA-3132764)
VEGFA [extracellular region]
(R-HSA-2975974)
0.808
5
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.77
6
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.748
4
UniProt:P98160 HSPG2
20
HSPG2(22-4196) [extracellular region]
(R-HSA-3827968)
HS(4)-HSPG2 [plasma membrane]
(R-HSA-2076698)
HS(6)-HSPG2 [plasma membrane]
(R-HSA-2076681)
HS(2)-HSPG2 [plasma membrane]
(R-HSA-2076659)
HS(1)-HSPG2 [plasma membrane]
(R-HSA-2076680)
HS(3)-HSPG2 [plasma membrane]
(R-HSA-2076627)
HS(5)-HSPG2 [plasma membrane]
(R-HSA-2076679)
HSPG2(3687-4391) [extracellular region]
(R-HSA-4088241)
XylS-HSPG2(22-4391) [Golgi lumen]
(R-HSA-2063972)
Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2064209)
HSPG2(22-4391) [Golgi lumen]
(R-HSA-2054109)
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2063971)
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
(R-HSA-2064023)
HS(3)-HSPG2 [Golgi lumen]
(R-HSA-2076384)
HS(4)-HSPG2 [Golgi lumen]
(R-HSA-2076495)
HS(2)-HSPG2 [Golgi lumen]
(R-HSA-2076426)
HS(1)-HSPG2 [Golgi lumen]
(R-HSA-2076366)
Heparan(4)-HSPG2 [Golgi lumen]
(R-HSA-2076395)
Heparan(3)-HSPG2 [Golgi lumen]
(R-HSA-2076334)
Heparan(2)-HSPG2 [Golgi lumen]
(R-HSA-2076335)
0.719
5
UniProt:P35916 FLT4
2
p-Y1063,Y1230-FLT4 [plasma membrane]
(R-HSA-9860553)
FLT4 [plasma membrane]
(R-HSA-195359)
0.702
5
UniProt:P49767 VEGFC
2
VEGFC [platelet alpha granule lumen]
(R-HSA-67159)
VEGFC [extracellular region]
(R-HSA-139887)
0.693
6
UniProt:Q12913 PTPRJ
2
PTPRJ [specific granule membrane]
(R-HSA-6799570)
PTPRJ [plasma membrane]
(R-HSA-6785269)
0.645
4
UniProt:O60565 GREM1
1
GREM1 [extracellular region]
(R-HSA-9831023)
0.639
4
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.602
3
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.589
2
UniProt:O75340 PDCD6
0.581
4
UniProt:P29350 PTPN6
5
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.573
2
UniProt:P29353 SHC1
5
p-Y-SHC1 [cytosol]
(R-HSA-162568)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
0.564
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.564
2
UniProt:P98160-PRO_0000391622 HSPG2
0.558
2
UniProt:P98160-PRO_0000391621 HSPG2
0.558
2
UniProt:Q9MYV3-3 VEGFA
0.522
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.499
3
UniProt:Q14114 LRP8
2
p-Y-LRP8 [plasma membrane]
(R-HSA-432136)
LRP8 [plasma membrane]
(R-HSA-432113)
0.471
2
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