VEGF binds to VEGFR leading to receptor dimerization

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R-HSA-195399
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Homo sapiens
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The binding of VEGF ligands to VEGFR receptors in the cell membrane induces dimerization and activation of the latter, initiating intracellular signaling cascades that result in proliferation, survival, migration and increased permeability of vascular endothelial cells (Matsumoto and Mugishima, 2006). The receptors predominantly form homodimers but heterodimers between VEGFR-1 and -2 have been observed. Although both VEGFR-1 and -2 are expressed in the vascular endothelium, the angiogenic activities of VEGFs are transduced mainly through VEGFR-2 in vivo.

Literature References
PubMed ID Title Journal Year
16835467 Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis

Matsumoto, T, Mugishima, H

J Atheroscler Thromb 2006
16633338 VEGF receptor signalling - in control of vascular function

Olsson, AK, Dimberg, A, Kreuger, J, Claesson-Welsh, L

Nat Rev Mol Cell Biol 2006
13678960 VEGF-receptor signal transduction

Cross, MJ, Dixelius, J, Matsumoto, T, Claesson-Welsh, L

Trends Biochem Sci 2003
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