TIMM9:TIMM10 transfers proteins to TIMM22

Stable Identifier
R-HSA-1955380
Type
Reaction
Species
Homo sapiens
Compartment
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TIMM9:TIMM10 with bound substrate protein interacts with FXC1 (TIMM9B, TIMM10B) and TIMM22 at the inner membrane (Muhlenbein et al. 2004). It is believed that TIMM22 then inserts the protein into the inner membrane and TIMM9:TIMM10 and FXC1 are released.

Literature References
PubMed ID Title Journal Year
18174896 Multiple pathways for sorting mitochondrial precursor proteins

Bolender, N, Sickmann, A, Wagner, R, Meisinger, C, Pfanner, N

EMBO Rep 2008
19453276 Multiple pathways for mitochondrial protein traffic

Endo, T, Yamano, K

Biol Chem 2009
14726512 Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria

M├╝hlenbein, N, Hofmann, S, Rothbauer, U, Bauer, MF

J Biol Chem 2004
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Orthologous Events
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