Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol

Stable Identifier
R-HSA-195690
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Zymosterol => cholesta-7,24-dien-3beta-ol
Locations in the PathwayBrowser
General
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Isomerization of zymosterol to cholesta-7,24-dien-3beta-ol is catalyzed by EBP in the endoplasmic reticulum. The biochemical details of the reaction have been established through studies of purified rat EBP; the role of the human enzyme has been established through studies of patients deficient in it (Derry et al. 1999; Braverman et al. 1999).

Literature References
PubMed ID Title Journal Year
10391218 Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com.

Derry, JM, Gormally, E, Means, GD, Zhao, W, Meindl, A, Kelley, RI, Boyd, Y, Herman, GE

Nat Genet 1999
10391219 Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome

Braverman, N, Lin, P, Moebius, FF, Obie, C, Moser, A, Glossmann, H, Wilcox, WR, Rimoin, DL, Smith, M, Kratz, L, Kelley, RI, Valle, D

Nat Genet 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid delta-isomerase activity of EBP [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created