Reactome | CANX [endoplasmic reticulum lumen]

CANX [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-195906

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

calnexin

Locations in the PathwayBrowser for interactor UniProt:P30101 PDIA3

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External Reference Information

External Reference

UniProt:P27824 CANX

Gene Names

CANX

Chain

signal peptide:1-20, chain:21-592

Reference Genes

COSMIC (genes):CANX P278242

dbSNP Gene:821 P278242

ENSEMBL:ENSG00000127022 CANX

Participates

as an input of

as an output of

as a component of

as a member of

CALR,CANX [endoplasmic reticulum lumen] (Homo sapiens)

This entity regulates

Positively

Glycosylation and Folding of HA (Homo sapiens)

Other forms of this molecule

CANX [lumenal side of endoplasmic reticulum membrane]

Inferred To

CANX [endoplasmic reticulum lumen] (Bos taurus)

CANX [endoplasmic reticulum lumen] (Caenorhabditis elegans)

CANX [endoplasmic reticulum lumen] (Canis familiaris)

CANX [endoplasmic reticulum lumen] (Gallus gallus)

CANX [endoplasmic reticulum lumen] (Mus musculus)

CANX [endoplasmic reticulum lumen] (Rattus norvegicus)

CANX [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

CANX [endoplasmic reticulum lumen] (Schizosaccharomyces pombe)

CANX [endoplasmic reticulum lumen] (Sus scrofa)

Cnx99A [endoplasmic reticulum lumen] (Drosophila melanogaster)

canx [endoplasmic reticulum lumen] (Danio rerio)

canx [endoplasmic reticulum lumen] (Xenopus tropicalis)

cnxA [endoplasmic reticulum lumen] (Dictyostelium discoideum)

Interactors (165)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.888	27
UniProt:P43307 SSR1	1	SSR1 [endoplasmic reticulum membrane] (R-HSA-444588)	0.773	7
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.725	5
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.69	5
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.671	5
UniProt:Q8N766 EMC1			0.671	5
UniProt:Q7LFX5 CHST15	1	CHST15 [Golgi membrane] (R-HSA-1971543)	0.669	3
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.644	5
UniProt:Q14703 MBTPS1	4	MBTPS1 [Golgi membrane] (R-HSA-381108) MBTPS1 [endoplasmic reticulum membrane] (R-HSA-6797334) p-MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956924) MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956733)	0.643	3
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.643	3
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.643	3
UniProt:Q9UIQ6 LNPEP	3	LNPEP [cytoplasmic vesicle membrane] (R-HSA-1445121) LNPEP [early endosome lumen] (R-HSA-1236834) LNPEP [cytosol] (R-HSA-983098)	0.643	3
UniProt:O94905 ERLIN2	3	EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520)	0.643	3
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.643	5
UniProt:Q9H741 SPRNG			0.643	3
UniProt:Q8NCH0 CHST14	9	CHST14 K69* [Golgi membrane] (R-HSA-3636891) CHST14 R135G [Golgi membrane] (R-HSA-3636924) CHST14 C289S [Golgi membrane] (R-HSA-3636925) CHST14 V49* [Golgi membrane] (R-HSA-3636926) CHST14 R213P [Golgi membrane] (R-HSA-3636894) CHST14 Y293C [Golgi membrane] (R-HSA-3636927) CHST14 P281L [Golgi membrane] (R-HSA-3636880) CHST14 L137Q [Golgi membrane] (R-HSA-5649488) CHST14 [Golgi membrane] (R-HSA-1971536)	0.643	3
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.643	3
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.623	3
UniProt:P35610 SOAT1	1	SOAT1 [endoplasmic reticulum membrane] (R-HSA-8876490)	0.615	4
UniProt:Q9H3N1 TMX1			0.615	6
UniProt:O00115 DNASE2	2	DNASE2 [Golgi lumen] (R-HSA-434322) DNASE2 [lysosomal lumen] (R-HSA-429822)	0.589	2
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.576	8
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.569	3
UniProt:P08069 IGF1R	3	p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180)	0.569	3
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.569	4
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.569	3
UniProt:P39656 DDOST	3	DDOST [plasma membrane] (R-HSA-879386) DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.569	5
UniProt:Q96AG4 LRC59			0.569	4
UniProt:O14967 CLGN			0.569	3
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.569	4
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.569	4
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.569	4
UniProt:Q8NFQ8 TOIP2			0.569	3
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.569	3
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.569	5
UniProt:O75787 ATP6AP2	3	ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921) ATP6AP2 [plasma membrane] (R-HSA-2022356)	0.569	4
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.569	3
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.569	4
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.569	3
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.569	3
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.569	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.569	4
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.569	4
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.569	4
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.569	4
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.569	4
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.569	3
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.569	3
UniProt:Q921T2	1	Tor1aip1 [cytosol] (R-MMU-9715083)	0.564	2
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.564	2
UniProt:Q8NBM8 PCYOX1L	2	PCYOX1L [extracellular region] (R-HSA-8862953) PCYOX1L [platelet alpha granule lumen] (R-HSA-8862980)	0.527	2
UniProt:Q9Y2A9 B3GNT3	1	B3GNT3 [Golgi membrane] (R-HSA-916819)	0.527	3
UniProt:P36897 TGFBR1	13	p-4S,T185,T186-TGFBR1 [plasma membrane] (R-HSA-170849) TGFBR1 [plasma membrane] (R-HSA-170839) TGFBR1 P83S [plasma membrane] (R-HSA-3656326) TGFBR1 P83L [plasma membrane] (R-HSA-3656341) TGFBR1 N45S [plasma membrane] (R-HSA-3656348) TGFBR1 C41Y [plasma membrane] (R-HSA-3656328) TGFBR1 G52R [plasma membrane] (R-HSA-3656368) p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] (R-HSA-3656509) p-4S,T185,T186-TGFBR1 R414* [plasma membrane] (R-HSA-3656508) p-4S,T185,T186-TGFBR1 L354Nfs4 [plasma membrane] (R-HSA-3656506) p-4S,T185,T186-TGFBR1 P327Qfs8 [plasma membrane] (R-HSA-3656505) p-4S,T185,T186-TGFBR1 W242* [plasma membrane] (R-HSA-3656504) Ub-TGFBR1 [plasma membrane] (R-HSA-8869461)	0.527	2
UniProt:Q15165 PON2	1	PON2 [extracellular region] (R-HSA-8932636)	0.527	2
UniProt:O60512 B4GALT3	1	B4GALT3 [Golgi membrane] (R-HSA-975922)	0.527	2
UniProt:P06280 GLA	3	GLA [azurophil granule lumen] (R-HSA-6798777) GLA [extracellular region] (R-HSA-6806179) GLA [lysosomal lumen] (R-HSA-1605763)	0.527	2
UniProt:Q8WTV0 SCARB1			0.527	2
UniProt:Q6UWY0 ARSK	2	OxA-ARSK [endoplasmic reticulum lumen] (R-HSA-1614364) ARSK [endoplasmic reticulum lumen] (R-HSA-1609684)	0.527	3
UniProt:Q6PIU2 NCEH1	1	NCEH1 [endoplasmic reticulum membrane] (R-HSA-6813685)	0.527	2
UniProt:Q9UNL2 SSR3	1	SSR3 [endoplasmic reticulum membrane] (R-HSA-264973)	0.527	2
UniProt:Q9H1A3 METL9			0.527	2
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.527	2
UniProt:Q14982 OPCML	2	cleaved GPI-OPCML [extracellular region] (R-HSA-8941075) GPI-OPCML [plasma membrane] (R-HSA-8940828)	0.527	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.527	3
UniProt:Q9Y320 TMX2			0.527	3
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.527	2
UniProt:Q8IWF2 FXRD2			0.527	3
UniProt:Q9NV96 TMEM30A	3	TMEM30A [specific granule membrane] (R-HSA-6799526) TMEM30A [plasma membrane] (R-HSA-6806278) TMEM30A [azurophil granule membrane] (R-HSA-6799504)	0.527	2
UniProt:Q96EG1 ARSG	2	OxA-ARSG [endoplasmic reticulum lumen] (R-HSA-1614304) ARSG [endoplasmic reticulum lumen] (R-HSA-1614361)	0.527	2
UniProt:Q9Y2B1 RXLT1			0.527	2
UniProt:P54802 NAGLU	5	NAGLU R674C [lysosomal lumen] (R-HSA-2219558) NAGLU R674H [lysosomal lumen] (R-HSA-2219557) NAGLU R626* [lysosomal lumen] (R-HSA-2219568) NAGLU R297* [lysosomal lumen] (R-HSA-2219553) NAGLU(59-743) [lysosomal lumen] (R-HSA-1678772)	0.527	2
UniProt:Q9Y5X9 LIPG	1	LIPG [extracellular region] (R-HSA-6789318)	0.527	2
UniProt:Q86YC3 LRC33			0.527	2
UniProt:Q6PK18 OGFD3			0.527	3
UniProt:Q9NPC4 A4GALT	1	A4GALT [Golgi membrane] (R-HSA-9846476)	0.527	3
UniProt:Q8NE01 CNNM3			0.527	2
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:Q96MM7 HS6ST2	1	HS6ST2 [Golgi membrane] (R-HSA-2076353)	0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:Q9UKU6 TRHDE			0.527	2
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:P18507 GABRG2	1	GABRG2 [plasma membrane] (R-HSA-975350)	0.527	2
UniProt:Q17R55 F187B			0.527	2
UniProt:P04062 GBA1	2	GBA1 [lysosomal membrane] (R-HSA-1605775) Unfolded GBA [cytosol] (R-HSA-6813790)	0.527	2
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.527	2
UniProt:Q86T26 TM11B			0.527	2
UniProt:Q9UKJ8 ADAM21	1	ADAM21 [plasma membrane] (R-HSA-1297340)	0.527	3
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.527	3
UniProt:Q9C0B6 BRNP2			0.527	3
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:Q9H0U3 MAGT1	2	MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [plasma membrane] (R-HSA-4836523)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P51172 SCNN1D	1	SCNN1D [plasma membrane] (R-HSA-2671902)	0.527	2
UniProt:Q96JJ7 TMX3	2	TMX3 [plasma membrane] (R-HSA-8848896) TMX3 [platelet alpha granule membrane] (R-HSA-8848889)	0.527	3
UniProt:Q92820 GGH	4	GGH [tertiary granule lumen] (R-HSA-6800911) GGH [azurophil granule lumen] (R-HSA-6800950) GGH [extracellular region] (R-HSA-6799679) GGH [specific granule lumen] (R-HSA-6799639)	0.527	2
UniProt:Q92542 NCSTN	3	NCSTN [plasma membrane] (R-HSA-2534241) NCSTN [azurophil granule membrane] (R-HSA-6799220) NCSTN [endosome membrane] (R-HSA-9010085)	0.527	2
UniProt:Q03518 TAP1	3	TAP1 [endoplasmic reticulum membrane] (R-HSA-947474) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [phagocytic vesicle membrane] (R-HSA-1236845)	0.527	2
UniProt:Q86WK7 AMGO3			0.527	2
UniProt:Q7L1S5 CHST9			0.527	2
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.527	2
UniProt:Q9GZX3 CHST6	9	CHST6 [Golgi membrane] (R-HSA-1971537) CHST6 C102G [Golgi membrane] (R-HSA-3656470) CHST6 L200R [Golgi membrane] (R-HSA-3656454) CHST6 D203E [Golgi membrane] (R-HSA-3656437) CHST6 E274K [Golgi membrane] (R-HSA-3656420) CHST6 Y110C [Golgi membrane] (R-HSA-3656419) CHST6 K174R [Golgi membrane] (R-HSA-3656480) CHST6 L276P [Golgi membrane] (R-HSA-3656477) CHST6 R211W [Golgi membrane] (R-HSA-3656457)	0.527	2
UniProt:O75354 ENTPD6	1	ENTPD6 (77-484) [extracellular region] (R-HSA-8851464)	0.527	2
UniProt:P15812 CD1E			0.527	2
UniProt:Q9HB40 RISC			0.527	2
UniProt:P29016 CD1B	1	CD1B [plasma membrane] (R-HSA-197793)	0.527	3
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:Q4G148 GXLT1			0.527	3
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.527	2
UniProt:Q8IZF4 AGRG5			0.527	2
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.527	2
UniProt:Q9H4B8 DPEP3			0.527	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.527	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.527	2
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	3
UniProt:Q9Y2C2 UST	1	UST [Golgi membrane] (R-HSA-2022058)	0.527	3
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:Q6UWB1 IL27RA	4	IL27RA [plasma membrane] (R-HSA-448478) p-Y611-IL27RA [plasma membrane] (R-HSA-8950330) sIL27RA [extracellular region] (R-HSA-8950454) sIL27RA [cytoplasm] (R-HSA-8950653)	0.527	2
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	2
UniProt:Q13724 MOGS	3	MOGS F652L [endoplasmic reticulum membrane] (R-HSA-4839779) MOGS R486T [endoplasmic reticulum membrane] (R-HSA-4839818) MOGS [endoplasmic reticulum membrane] (R-HSA-532676)	0.527	2
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.527	2
UniProt:P40126 DCT	1	DCT [melanosome membrane] (R-HSA-5662685)	0.527	3
UniProt:P42892 ECE1	1	ECE1 [plasma membrane] (R-HSA-8876866)	0.527	2
UniProt:Q9UHC6-1 CNTNAP2			0.499	2
UniProt:P41143 OPRD1	1	OPRD1 [plasma membrane] (R-HSA-374265)	0.499	2
UniProt:P11607	2	ATP2A2 [platelet dense tubular network membrane] (R-SSC-427903) ATP2A2 [endoplasmic reticulum membrane] (R-SSC-391962)	0.499	2
UniProt:P0C739 BNL2A			0.491	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.483	2
UniProt:Q86Y07 VRK2	2	VRK2 [mitochondrial outer membrane] (R-HSA-9715102) VRK2 [endoplasmic reticulum membrane] (R-HSA-9714457)	0.483	3
UniProt:P51648 ALDH3A2	1	ALDH3A2 [cytosol] (R-HSA-9715204)	0.483	3
UniProt:Q9HCU5 PREB	1	PREB [endoplasmic reticulum membrane] (R-HSA-203984)	0.483	3
UniProt:O14579 COPE	4	COPE [endoplasmic reticulum membrane] (R-HSA-6810959) COPE [Golgi membrane] (R-HSA-6808743) COPE [transport vesicle] (R-HSA-6808745) COPE [cytosol] (R-HSA-199969)	0.483	3
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.483	3
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.483	3
UniProt:Q9P0I2 EMC3	1	EMC3 [endoplasmic reticulum membrane] (R-HSA-9714347)	0.483	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.483	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.483	2
UniProt:Q6ZNB6 NFXL1			0.483	2
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.483	2
UniProt:O43402 EMC8			0.483	2
UniProt:Q96A57 TM230			0.483	2
UniProt:Q9Y679 AUP1			0.483	2
UniProt:Q6NUS6 TCTN3	1	TCTN3 [ciliary membrane] (R-HSA-5626662)	0.483	3
UniProt:Q9NPA0 EMC7			0.483	3
UniProt:P11717 IGF2R	7	IGF2R [secretory granule membrane] (R-HSA-6803320) IGF2R [plasma membrane] (R-HSA-6806532) IGF2R [trans-Golgi network membrane] (R-HSA-6814608) IGF2R [transport vesicle] (R-HSA-6814609) IGF2R [cytoplasmic vesicle membrane] (R-HSA-434213) IGF2R [Golgi membrane] (R-HSA-434345) IGF2R [clathrin-coated endocytic vesicle membrane] (R-HSA-8869091)	0.483	2
UniProt:Q96S66 CLCC1			0.483	3
UniProt:Q5J8M3 EMC4			0.483	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.483	3
UniProt:P21860 ERBB3			0.483	3
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.483	2
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.483	3
UniProt:P61009 SPCS3	1	SPCS3 [endoplasmic reticulum membrane] (R-HSA-264916)	0.483	2
UniProt:Q96A33 CCD47			0.483	4
UniProt:P04234 CD3D	3	p-Y149,Y160-CD3D [plasma membrane] (R-HSA-202329) CD3D [plasma membrane] (R-HSA-198171) CD3D [clathrin-coated endocytic vesicle membrane] (R-HSA-8869079)	0.483	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.483	3
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.483	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.483	3
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.483	2
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.483	3
UniProt:Q9BTX1 NDC1	1	NDC1 [nuclear envelope] (R-HSA-6805183)	0.483	3
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P30050 RPL12	1	RPL12 [cytosol] (R-HSA-72408)	0.462	3

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