Dab2 is recruited to the junctional plaques

Stable Identifier
R-HSA-196026
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Dab2 is recruited to Cx43-based GJs possibly through a direct interaction between its N-terminal phosphotyrosine binding (PTB) domain and a putative XPXY internalization motif found in the C-terminal tail of Cx43 as well as a number of other connexin family members (Piehl et al., 2007).The distal portion of Dab2 on its opposite end binds the globular N-terminal domain of clathrin heavy chains (Piehl et al., 2007).

Literature References
PubMed ID Title Journal Year
17108328 Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process

Piehl, M, Lehmann, C, Gumpert, A, Denizot, JP, Segretain, D, Falk, MM

Mol Biol Cell 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed