Reactome | ACTG1 [lysosomal membrane]

ACTG1 [lysosomal membrane]

Stable Identifier

R-HSA-196169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

cytoplasmic actin 2

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction degradation (Homo sapiens)
        
        Internalization of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        F-actin [lysosomal membrane] (Homo sapiens)
        
        actin [lysosomal membrane] (Homo sapiens)
        
        ACTG1 [lysosomal membrane] (Homo sapiens)
        
        Lysosomal degradation of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        F-actin [lysosomal membrane] (Homo sapiens)
        
        actin [lysosomal membrane] (Homo sapiens)
        
        ACTG1 [lysosomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63261 ACTG1

Gene Names

ACTG1, ACTG

Chain

chain:1-375, initiator methionine:, chain:2-375

Reference Genes

BioGPS Gene:71 ACTG1

COSMIC (genes):ACTG1 ACTG1

CTD Gene:71 ACTG1

dbSNP Gene:71 ACTG1

ENSEMBL:ENSG00000184009 ACTG1

ENSEMBL_homo_sapiens_GENE:ENSG00000184009.13 ACTG1

ENSEMBL_homo_sapiens_GENE:ENSG00000291420.1 ACTG1

HGNC:144 ACTG1

KEGG Gene (Homo sapiens):71 ACTG1

Monarch:71 ACTG1

NCBI Gene:71 ACTG1

OMIM:102560 ACTG1

UCSC:P63261 ACTG1

Reference Transcript

Other Identifiers

11752959_x_at

11754217_x_at

11757807_x_at

11758042_x_at

11762785_x_at

16849849

201550_3p_x_at

201550_PM_x_at

201550_x_at

211970_PM_x_at

211970_x_at

211983_PM_x_at

211983_x_at

211995_3p_x_at

211995_PM_x_at

211995_x_at

212363_3p_x_at

212363_PM_x_at

212363_x_at

212988_PM_x_at

212988_x_at

213214_3p_x_at

213214_PM_x_at

213214_x_at

221607_3p_x_at

221607_PM_x_at

221607_x_at

224585_3p_x_at

224585_PM_x_at

224585_x_at

2349440

2387414

2644947

34160_at

3621802

3773933

3773934

3773935

3773936

3773937

3773938

3773940

3773942

3773946

3773947

3773948

3773949

3773951

3773952

3773953

3773954

3773956

3773969

43831_s_at

51746_f_at

8019183

A_23_P44037

GE80152

GO:0000166

GO:0001525

GO:0001738

GO:0002376

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005522

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0007010

GO:0007155

GO:0007409

GO:0010628

GO:0015629

GO:0016020

GO:0016192

GO:0016787

GO:0019901

GO:0030016

GO:0030154

GO:0030335

GO:0030424

GO:0031410

GO:0031625

GO:0031941

GO:0034330

GO:0035267

GO:0035633

GO:0042060

GO:0042802

GO:0043226

GO:0043296

GO:0044305

GO:0045177

GO:0045202

GO:0045214

GO:0045335

GO:0048856

GO:0048870

GO:0051492

GO:0051893

GO:0070062

GO:0070527

GO:0071346

GO:0072562

GO:0090303

GO:0097433

GO:0098542

GO:0098685

GO:0098973

GO:0098974

GO:0120192

GO:0120220

GO:0150111

GO:1900242

GO:1902396

HMNXSV003039797

HMNXSV003044768

Hs.14376.2.A1_3p_x_at

Hs.14376.3.A1_3p_a_at

Hs.14376.3.A1_3p_x_at

Hs.14376.4.A1_3p_x_at

Hs.14376.5.A1_3p_a_at

Hs.14376.5.A1_3p_x_at

Hs.14376.6.S1_3p_a_at

Hs.14376.6.S1_3p_s_at

Hs.14376.7.A1_3p_a_at

Hs.14376.7.A1_3p_x_at

Hs.14376.9.A1_3p_a_at

Hs.14376.9.A1_3p_x_at

ILMN_1704961

ILMN_2053178

M19283_at

PH_hs_0028775

PH_hs_0031012

TC06001971.hg

TC17001952.hg

TC17002825.hg

g11038618_3p_a_at

g11038618_3p_s_at

g12804934_3p_a_at

g12804934_3p_s_at

g12804934_3p_x_at

Participates

as a candidate of

actin [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

ACTG1 [cytosol]

ACTG1 [plasma membrane]

Inferred To

ACTG1 [lysosomal membrane] (Bos taurus)

ACTG1 [lysosomal membrane] (Canis familiaris)

ACTG1 [lysosomal membrane] (Gallus gallus)

ACTG1 [lysosomal membrane] (Sus scrofa)

Act42A [lysosomal membrane] (Drosophila melanogaster)

Homologues of ACTG1 [lysosomal membrane] (Caenorhabditis elegans)

Homologues of ACTG1 [lysosomal membrane] (Drosophila melanogaster)

Actg1 [lysosomal membrane] (Mus musculus)

Actg1 [lysosomal membrane] (Rattus norvegicus)

act-2 [lysosomal membrane] (Caenorhabditis elegans)

act-3 [lysosomal membrane] (Caenorhabditis elegans)

act-4 [lysosomal membrane] (Caenorhabditis elegans)

Act5C [lysosomal membrane] (Drosophila melanogaster)

act-1 [lysosomal membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001605.1, NP_001186883.1

OpenTargets

ENSG00000184009

HPA

ENSG00000184009-ACTG1

GeneCards

P63261

Ensembl

ENSP00000459119, ENST00000681842, ENSP00000477968, ENST00000570382, ENST00000575994, ENST00000576544, ENST00000575659, ENSP00000505060, ENSP00000506253, ENST00000573283, ENSP00000458162, ENSG00000184009, ENST00000575087, ENST00000615544, ENST00000575842, ENSP00000459124, ENST00000681052, ENST00000571721, ENST00000680227, ENSP00000460464, ENST00000679480, ENSP00000505193, ENSP00000466346, ENSP00000461672, ENST00000680727, ENSP00000460660, ENSP00000458435, ENST00000679778, ENSP00000506126, ENSP00000505235, ENSP00000506201

PRO

P63261

Pharos - Targets

P63261

Orphanet

17680

PDB

8DNF, 7NVM, 6WK1, 6G2T, 6V63, 6CXJ, 6CXI, 6WK2, 6V62, 5JLH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.951	16
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.831	10
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.65	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.602	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.564	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.483	2

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