MATK (CSK homologous kinase) binds phosphorylated ERBB2

Stable Identifier
R-HSA-1963563
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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MATK (also known as CHK or CSK homologous kinase) binds to ERBB2 through phosphorylated tyrosine residue Y1253 in the C-tail of ERBB2 and, through an unknown mechanism, inhibits ERBB2 downstream signaling.
Literature References
PubMed ID Title Journal Year
9461599 Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation

McShan, G, Zrihan-Licht, S, Avraham, H, Keydar, I, Yarden, Y, Deng, B

J Biol Chem 1998
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