17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol

Stable Identifier
R-HSA-196372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
17-hydroxypregnenolone + NAD+ => pregn-5-ene-3,20-dione-17-ol + NADH + H+
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17-Hydroxypregnenolone and NAD+ react to form pregn-5-ene-3,20-dione-17-ol and NADH + H+. This reaction is catalyzed by the 3 beta-hydroxysteroid activity of 3-beta-hydroxysteroid dehydrogenase/isomerase (HSD3B) enzyme associated with the endoplasmic reticulum membrane. The active form of the enzyme is a homodimer. The enzyme occurs in two isoforms that are similar in their biochemical properties but differ in their tissue expression: type I (HSD3B1) is found in placenta and skin, while type II (HSD3B2) is found in the adrenal glands and gonads.

Literature References
PubMed ID Title Journal Year
1944309 Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads

Rheaume, E, Lachance, Y, Zhao, HF, Breton, N, Dumont, M, de Launoit, Y, Trudel, C, Luu-The, V, Simard, J, Labrie, F

Mol Endocrinol 1991
2770297 Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes

Thomas, JL, Myers, RP, Strickler, RC

J Steroid Biochem 1989
12832414 Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase

Thomas, JL, Duax, WL, Addlagatta, A, Brandt, S, Fuller, RR, Norris, W

J Biol Chem 2003
2243100 Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

Lachance, Y, Luu-The, V, Labrie, C, Simard, J, Dumont, M, de Launoit, Y, Guerin, S, Leblanc, G, Labrie, F

J Biol Chem 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-beta-hydroxy-delta5-steroid dehydrogenase activity of HSD2B1 or HSD3B2 dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created