Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol

Stable Identifier
R-HSA-196402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cholesta-5,7,24-trien-3beta-ol + NADPH + H+ => desmosterol + NADP+
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Cholesta-5,7,24-trien-3beta-ol and NADPH + H+ react to form desmosterol and NADP+. This reaction is catalyzed by DHCR7, associated with the endoplasmic reticulum membrane. The biochemical details of the reaction are inferred from those of the reaction catalyzed by the well-studied rat enzyme (Bae et al. 1999).

Literature References
PubMed ID Title Journal Year
9465114 Molecular cloning and expression of the human delta7-sterol reductase

Moebius, FF, Fitzky, BU, Lee, JN, Paik, YK, Glossmann, H

Proc Natl Acad Sci U S A 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created