Reduction of desmosterol to cholesterol

Stable Identifier
R-HSA-196417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
desmosterol + NADPH + H+ => cholesterol + NADP+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Desmosterol is reduced by NADPH + H+ to form cholesterol and NADP+, catalyzed by DHCR24 associated with the endoplasmic reticulum membrane.

Literature References
PubMed ID Title Journal Year
11519011 Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

Waterham, HR, Koster, J, Romeijn, GJ, Hennekam, RC, Vreken, P, Andersson, HC, FitzPatrick, DR, Kelley, RI

Am J Hum Genet 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created