Reactome | DHCR7 [endoplasmic reticulum membrane]

DHCR7 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-196423

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

7-dehydrocholesterol reductase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UBM7 DHCR7

Gene Names

DHCR7, D7SR

Chain

chain:1-475

Reference Genes

BioGPS Gene:1717 DHCR7

COSMIC (genes):DHCR7 DHCR7

CTD Gene:1717 DHCR7

dbSNP Gene:1717 DHCR7

ENSEMBL:ENSG00000172893 DHCR7

ENSEMBL_homo_sapiens_GENE:ENSG00000172893.18 DHCR7

HGNC:2860 DHCR7

KEGG Gene (Homo sapiens):1717 DHCR7

Monarch:1717 DHCR7

NCBI Gene:1717 DHCR7

OMIM:602858 DHCR7

UCSC:Q9UBM7 DHCR7

Reference Transcript

Other Identifiers

11743808_a_at

16741501

1717

201790_PM_s_at

201790_s_at

201791_PM_s_at

201791_s_at

3380696

3380698

3380699

3380700

3380701

3380702

3380706

3380708

3380709

3380710

3380712

3380713

3380714

3380716

3380718

3380719

3380720

3380721

39059_at

7950067

A_23_P24444

GE81013

GO:0003824

GO:0005515

GO:0005634

GO:0005635

GO:0005640

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0008202

GO:0008203

GO:0009918

GO:0016020

GO:0016126

GO:0016132

GO:0016491

GO:0016627

GO:0016628

GO:0033489

GO:0033490

GO:0043226

GO:0047598

GO:0050661

GO:1901617

HMNXSV003018215

Hs.11806.0.A1_3p_a_at

ILMN_1815626

ILMN_2165867

PH_hs_0001117

TC11002038.hg

g4503320_3p_a_at

Participates

as an output of

Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)

Inferred To

dhcr-7 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

DHCR7 [endoplasmic reticulum membrane] (Bos taurus)

DHCR7 [endoplasmic reticulum membrane] (Canis familiaris)

DHCR7 [endoplasmic reticulum membrane] (Danio rerio)

DHCR7 [endoplasmic reticulum membrane] (Gallus gallus)

DHCR7 [endoplasmic reticulum membrane] (Mus musculus)

DHCR7 [endoplasmic reticulum membrane] (Rattus norvegicus)

DHCR7 [endoplasmic reticulum membrane] (Sus scrofa)

DHCR7 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001351.2, NP_001157289.1

OpenTargets

ENSG00000172893

ZINC - Substances

DHCR7_HUMAN

HPA

ENSG00000172893-DHCR7

GeneCards

Q9UBM7

ZINC target

Q9UBM7

Ensembl

ENST00000526780, ENSP00000435707, ENSP00000347717, ENSP00000384739, ENSG00000172893, ENSP00000435668, ENST00000525346, ENST00000407721, ENST00000355527

PRO

Q9UBM7

Pharos - Targets

Q9UBM7

Orphanet

15862

ZINC - Predictions - Purchasable

DHCR7_HUMAN

HMDB Protein

HMDBP00548

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	8

Cite Us!