Reactome | STING binds TRIM32 or TRIM56

STING binds TRIM32 or TRIM56

Stable Identifier

R-HSA-1964496

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Tripartite motif (TRIM) family member TRIM56 was shown to interact with STING upon DNA stimulation promoting lysine 63-linked ubiquitination of STING and type I IFN induction (Tsuchida T et al. 2010). Another member of the family TRIM32 has also been implicated in K63-linked ubiquitination of STING (Zhang J et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
21074459	The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA Kawai, T, Abe, T, Akira, S, Matsuura, Y, Kumar, H, Zou, J, Tsuchida, T, Saitoh, T	Immunity	2010
22745133	TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination Hu, MM, Zhang, J, Shu, HB, Wang, YY	J. Biol. Chem.	2012