COASY phosphorylates DP-CoA

Stable Identifier
R-HSA-196773
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3'-dephospho-CoA + ATP => ADP + CoA + H(+), Phosphorylation of dephospho-CoA to produce CoA
ReviewStatus
5/5
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The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).
Literature References
PubMed ID Title Journal Year
14514684 Subcellular localization and regulation of coenzyme A synthase

Panasyuk, G, Kyyamova, R, Lyzogubov, V, Zhyvoloup, A, Filonenko, V, Valovka, T, Nemazanyy, I, Gorbenko, O, Wang, ML, Fenton, T, Foxon, R, Gout, IT, Matsuka, G, Rebholz, H, Usenko, V

J Biol Chem 2003
11994049 Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)

Worrall, DM, Aghajanian, S

Biochem J 2002
Participants
Participates
Catalyst Activity

dephospho-CoA kinase activity of COASY [mitochondrial outer membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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