There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Biotin transport and metabolism

Stable Identifier
R-HSA-196780
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.

Literature References
PubMed ID Title Journal Year
19319844 Biotin Biofactors 2009
Participants
Participant Of
Event Information
Go Biological Process
Orthologous Events