Reactome: A Curated Pathway Database

Biotin transport and metabolism

Stable Identifier
R-HSA-196780
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.

Literature References
PubMed ID Title Journal Year
19319844 Biotin Biofactors 2009
Participants
Participant Of
Orthologous Events