Nicotinate metabolism

Stable Identifier
R-HSA-196807
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan (Magni et al. 2004).

Literature References
PubMed ID Title Journal Year
14704851 Enzymology of NAD+ homeostasis in man Cell Mol Life Sci 2004
Participants
Participant Of
Event Information
Go Biological Process
Orthologous Events