FLAD1 phosphorylates FMN

Stable Identifier
R-HSA-196929
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ATP + FMN + H(+) => diphosphate + FAD, FMN is futher phosphorylated to FAD
ReviewStatus
5/5
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FMN can be phosphorylated and adenylated to produce the second cofactor from riboflavin origins, flavin adenine dinucleotide (FAD). The enzyme responsible , FMN adenylyltransferase (FLAD1 aka FAD synthase), is cytosolic and transfers a phosphate and an adenyl group from ATP to form FAD.
Literature References
PubMed ID Title Journal Year
16643857 Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase

Indiveri, C, Brizio, C, Bafunno, V, Galluccio, M, Wait, R, Accardi, R, Torchetti, EM, Barile, M, Gianazza, E

Biochem Biophys Res Commun 2006
Participants
Participates
Catalyst Activity

FMN adenylyltransferase activity of FLAD1 [cytosol]

Orthologous Events
Cross References
Rhea
Reviewed
Created
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