FLAD1 phosphorylates FMN

Stable Identifier
R-HSA-196929
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
FMN is futher phosphorylated to FAD
Locations in the PathwayBrowser
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FMN can be phosphorylated and adenylated to produce the second cofactor from riboflavin origins, flavin adenine dinucleotide (FAD). The enzyme responsible , FMN adenylyltransferase (FLAD1 aka FAD synthase), is cytosolic and transfers a phosphate and an adenyl group from ATP to form FAD.

Literature References
PubMed ID Title Journal Year
16643857 Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase

Brizio, C, Galluccio, M, Wait, R, Torchetti, EM, Bafunno, V, Accardi, R, Gianazza, E, Indiveri, C, Barile, M

Biochem Biophys Res Commun 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
FMN adenylyltransferase activity of FLAD1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created