2xENPP1 hydrolyzes FAD to FMN

Stable Identifier
R-HSA-196955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
FAD + H2O => AMP + FMN + 2 H(+), FAD can be hydrolyzed back to FMN
ReviewStatus
5/5
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2xENPP1 hydrolyzes FAD to FMN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphatase action on flavin adenine dinucleotide (FAD) can reform flavin mononucleotide (FMN). The enzyme performing the reaction is nucleotide pyrophosphatase (ENPP1) and it exists as a homodimer on the plasma membrane.
Literature References
Participants
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Output
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as an event of
Catalyst Activity

nucleotide diphosphatase activity of 2xENPP1 [plasma membrane]

Physical Entity
2xENPP1 [plasma membrane] (Homo sapiens)
Activity
nucleotide diphosphatase activity (GO:0004551)
Orthologous Events
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
Cross References
Rhea
Reviewed
Hill, DP  (2023-07-26)
Created
Jassal, B  (2007-04-27)
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