The addition of GalNAc to the terminal glucuronate residue forms chondroitin

Stable Identifier
R-HSA-1971482
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Chondroitin sulfate N-acetylgalactosaminyltransferases 1 and 2 (CSGALNACT1 and 2) (Uyama et al. 2002, Gotoh et al. 2002) transfer N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the glucuronate (GlcA) residue of the linker sequence. This first addition to the linker determines this GAG to be chondroitin. Chondroitin is comprised of the repeating disaccharide unit GalNAc-GlcA.

Literature References
PubMed ID Title Journal Year
12163485 Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis

Gotoh, M, Sato, T, Akashima, T, Iwasaki, H, Kameyama, A, Mochizuki, H, Yada, T, Inaba, N, Zhang, Y, Kikuchi, N, Kwon, YD, Togayachi, A, Kudo, T, Nishihara, S, Watanabe, H, Kimata, K, Narimatsu, H

J Biol Chem 2002
11788602 Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate

Uyama, T, Kitagawa, H, Tamura Ji, J, Sugahara, K

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of CSGALNACT [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created