QPRT transfers PRIB to QUIN to form NAMN

Stable Identifier
R-HSA-197268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
A phospho-ribosyl group is added to quinolinate
Locations in the PathwayBrowser
General
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The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+.

Literature References
PubMed ID Title Journal Year
9473669 Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase

Fukuoka, SI, Nyaruhucha, CM, Shibata, K

Biochim Biophys Acta 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nicotinate-nucleotide diphosphorylase (carboxylating) activity of QPRT [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created