NADSYN1 hexamer amidates NAAD to NAD+

Stable Identifier
R-HSA-197271
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Amidation of deamino-NAD+ to NAD+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NAD synthases 1 and 2 (NADSYN1 and NADSYN2) catalyse the final step in the biosynthesis of NAD+, both in de novo synthesis and in the salvage pathway. The enzymes makes use of an amide donor in the reaction. NADSYNs exist as a homohexamers in the cytosol. The major difference between the two forms is that NADSYN1 appears to be glutamine-dependent whereas NADSYN2 is strictly ammonia-dependent (Hara et al. 2003).

Literature References
PubMed ID Title Journal Year
12547821 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.

Hara, N, Yamada, K, Terashima, M, Osago, H, Shimoyama, M, Tsuchiya, M

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created