Reactome | CD226 [plasma membrane]

CD226 [plasma membrane]

Stable Identifier

R-HSA-197562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD226 antigen precursor, C226_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P21359 NF1

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External Reference Information

External Reference

UniProt:Q15762 CD226

Gene Names

CD226, DNAM1

Chain

signal peptide:1-18, chain:19-336

Reference Genes

BioGPS Gene:10666 CD226

COSMIC (genes):CD226 CD226

CTD Gene:10666 CD226

dbSNP Gene:10666 CD226

ENSEMBL:ENSG00000150637 CD226

HGNC:16961 CD226

KEGG:hsa:10666 CD226

Monarch:10666 CD226

NCBI Gene:10666 CD226

OMIM:605397 CD226

UCSC:Q15762 CD226

Reference Transcript

Other Identifiers

10666

11737251_at

11756610_a_at

16855810

207315_PM_at

207315_at

33575_at

3812382

3812384

3812386

3812387

3812388

3812389

3812390

3812391

3812392

3812393

3812394

3812395

3812402

3812403

3812404

3812405

3812416

3812417

3812419

3812420

3812421

3812422

3812423

3812424

3812425

42531_at

8023757

A_23_P78330

A_32_P125917

A_32_P30434

A_33_P3413558

GE474446

GE819720

GO:0002729

GO:0002860

GO:0002891

GO:0005178

GO:0005515

GO:0005886

GO:0007155

GO:0007165

GO:0008037

GO:0009897

GO:0009986

GO:0016020

GO:0019901

GO:0032729

GO:0033005

GO:0038023

GO:0042267

GO:0042802

GO:0045121

GO:0045954

GO:0050839

GO:0050862

GO:0060369

HMNXSV003047031

HMNXSV003055961

ILMN_1687825

PH_hs_0006961

PH_hs_0024112

TC18000566.hg

U56102_at

g5729807_3p_at

Participates

as a component of

as an input of

Inferred To

CD226 [plasma membrane] (Canis familiaris)

CD226 [plasma membrane] (Gallus gallus)

CD226 [plasma membrane] (Sus scrofa)

cd226 [plasma membrane] (Danio rerio)

Cd226 [plasma membrane] (Mus musculus)

Cd226 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_005266699.1, NP_001290547.1, XP_047293231.1, XP_047293230.1, NP_006557.2

Guide to Pharmacology - Targets

3295

OpenTargets

ENSG00000150637

ENSEMBL

ENSP00000280200, ENSG00000150637, ENSP00000461947, ENST00000280200, ENST00000582621

HPA

ENSG00000150637-CD226

GeneCards

CD226

PRO

Q15762

Pharos - Targets

Q15762

GlyGen

Q15762

PDB

6ISB, 6O3O

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.862	7
UniProt:Q15762 CD226	1	CD226 [plasma membrane] (R-HSA-197562)	0.609	2
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.609	3
UniProt:Q495A1 TIGIT			0.563	4
UniProt:Q13445 TMED1			0.527	2
UniProt:Q14232 EIF2B1	1	EIF2B1 [cytosol] (R-HSA-72517)	0.527	2
UniProt:Q13144 EIF2B5	1	EIF2B5 [cytosol] (R-HSA-72523)	0.527	2
UniProt:P21359 NF1	20	NF1 R816* [cytosol] (R-HSA-6802424) NF1 F1464L [cytosol] (R-HSA-6802410) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616Gfs4 [cytosol] (R-HSA-9647468) NF1 R2450 [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845Vfs33 [cytosol] (R-HSA-9647486) NF1(2-2839) [cytosol] (R-HSA-947770) ub-NF1(2-2839) [cytosol] (R-HSA-5658418) NF1 R69Nfs7 [cytosol] (R-HSA-9647505) NF1 R440* [cytosol] (R-HSA-9647511) NF1 R440Q [cytosol] (R-HSA-9647508) NF1 G849E fs*29 [cytosol] (R-HSA-9656596)	0.527	2
UniProt:Q8N8L6 ARL10			0.527	2
UniProt:P27338 MAOB	1	MAOB [mitochondrial outer membrane] (R-HSA-141194)	0.527	2
UniProt:Q9NR50 EIF2B3	1	EIF2B3 [cytosol] (R-HSA-72525)	0.527	2
UniProt:Q9UHG3 PCYOX			0.527	2
UniProt:Q8IY95 TM192			0.527	2
UniProt:Q9C0H2 TTYH3	1	TTYH3 [plasma membrane] (R-HSA-2744243)	0.527	2
UniProt:Q9H1E5 TMX4			0.527	2
UniProt:Q9HD20 ATP13A1	1	ATP13A1 [endoplasmic reticulum membrane] (R-HSA-939749)	0.527	2
UniProt:Q68D91 MBLC2			0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q9H6R6 ZDHC6			0.527	2
UniProt:O00255 MEN1	4	MEN1 [nucleoplasm] (R-HSA-2186626) MEN1 [cytosol] (R-HSA-5672315) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901)	0.527	2
UniProt:P42356 PI4KA	1	PI4KA [cytosol] (R-HSA-1604653)	0.527	2
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.527	2
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.527	2

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