Reactome | AGER [plasma membrane]

AGER [plasma membrane]

Stable Identifier

R-HSA-197639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RAGE, Advanced glycosylation end product-specific receptor precursor

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Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88

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External Reference Information

External Reference

UniProt:Q15109 AGER

Gene Names

AGER, RAGE

Chain

signal peptide:1-22, chain:23-404

Reference Genes

BioGPS Gene:177 AGER

COSMIC (genes):AGER AGER

CTD Gene:177 AGER

dbSNP Gene:177 AGER

ENSEMBL:ENSG00000204305 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000204305.16 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000206320.12 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000229058.10 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000230514.11 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000231268.9 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000234729.9 AGER

ENSEMBL_homo_sapiens_GENE:ENSG00000237405.10 AGER

HGNC:320 AGER

KEGG Gene (Homo sapiens):177 AGER

Monarch:177 AGER

NCBI Gene:177 AGER

OMIM:600214 AGER

UCSC:Q15109 AGER

Reference Transcript

Other Identifiers

11726044_a_at

11726045_x_at

11741861_a_at

11741862_x_at

11745620_x_at

11750365_x_at

11753676_x_at

11753713_x_at

11756033_x_at

11762194_x_at

17026994

17029594

17034585

17037086

17039794

17042290

177

210081_PM_at

210081_at

217046_PM_s_at

217046_s_at

2949831

2949832

2949833

2949834

2949836

2949837

2949838

2949839

2949840

2949841

2949843

2949844

2949845

2949846

2949847

2949850

2949851

2949852

2949854

2949856

35868_at

8125341

8178771

8179967

A_23_P93360

A_33_P3396008

A_33_P3396010

GE58136

GE79532

GO:0001540

GO:0001650

GO:0001666

GO:0001774

GO:0001914

GO:0001934

GO:0002376

GO:0003013

GO:0004888

GO:0005044

GO:0005055

GO:0005515

GO:0005576

GO:0005634

GO:0005730

GO:0005886

GO:0006351

GO:0006355

GO:0006897

GO:0006954

GO:0007155

GO:0007166

GO:0007611

GO:0009611

GO:0009986

GO:0010255

GO:0014002

GO:0016020

GO:0016192

GO:0016324

GO:0023052

GO:0030054

GO:0030154

GO:0031175

GO:0032693

GO:0032722

GO:0032731

GO:0032735

GO:0032755

GO:0032760

GO:0034116

GO:0036211

GO:0038023

GO:0038024

GO:0042104

GO:0042802

GO:0043226

GO:0044548

GO:0044877

GO:0045056

GO:0046330

GO:0048143

GO:0048167

GO:0048856

GO:0048870

GO:0050727

GO:0050785

GO:0050877

GO:0050930

GO:0051092

GO:0060089

GO:0060090

GO:0070374

GO:0071639

GO:0072657

GO:0098631

GO:0098794

GO:0150003

GO:0150104

GO:1900271

GO:1900272

GO:1900453

GO:1900744

GO:1900745

GO:1901222

GO:1901224

GO:1902961

GO:1903523

GO:1904472

GO:1904645

GO:1904646

GO:2000439

GO:2000514

GO:2001200

HMNXSV003055993

Hs.184.1.S1_3p_at

Hs.184.1.S1_3p_x_at

ILMN_1690829

ILMN_1729777

ILMN_2257015

TC06003599.hg

TC06004049.hg

U89336_cds3_at

g6691625_3p_a_at

g6691625_3p_x_at

Participates

as an input of

Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)

as a component of

AGER ligands:AGER [plasma membrane] (Homo sapiens)

Inferred To

hmcn2 [plasma membrane] (Xenopus tropicalis)

AGER [plasma membrane] (Bos taurus)

AGER [plasma membrane] (Canis familiaris)

AGER [plasma membrane] (Dictyostelium discoideum)

AGER [plasma membrane] (Sus scrofa)

Ager [plasma membrane] (Mus musculus)

Ager [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001193861.1, NP_001193858.1, NP_001193865.1, NP_001193895.1, NP_001127.1, NP_751947.1, NP_001193863.1, NP_001193883.1, NP_001193869.1

Guide to Pharmacology - Targets

2843

OpenTargets

ENSG00000204305

ZINC - Substances

RAGE_HUMAN

GeneCards

Q15109

HPA

ENSG00000204305-AGER

ZINC target

Q15109

Ensembl

ENSP00000447301, ENST00000548464, ENST00000456918, ENSG00000234729, ENSP00000399686, ENSP00000416042, ENSP00000364195, ENST00000441180, ENSP00000449708, ENST00000375076, ENST00000427822, ENST00000453588, ENSP00000364217, ENSP00000400667, ENSP00000364210, ENSP00000413391, ENST00000375069, ENSP00000448979, ENSG00000231268, ENST00000449037, ENST00000383279, ENST00000383275, ENSP00000372766, ENSP00000446835, ENSP00000388462, ENSP00000448579, ENST00000547328, ENSP00000372762, ENSG00000204305, ENSP00000409457, ENST00000375055, ENST00000447921, ENST00000547651, ENSG00000230514, ENST00000432831, ENSP00000395812, ENSP00000401068, ENSP00000397227, ENSP00000449042, ENST00000426138, ENSP00000450134, ENST00000549758, ENST00000441804, ENSP00000387887, ENST00000550562, ENST00000551827, ENSG00000237405, ENSP00000449226, ENSP00000364208, ENST00000551254, ENST00000436456, ENSP00000387853, ENST00000375067, ENST00000451115, ENSP00000391743, ENSG00000229058, ENST00000412470, ENST00000551381, ENSG00000206320, ENSP00000415144, ENST00000438221

PRO

Q15109

Pharos - Targets

Q15109

ZINC - Predictions - Purchasable

RAGE_HUMAN

PDB

2MOV, 6XQ1, 4P2Y, 3O3U, 4LP4, 6XQ3, 2LMB, 7LMW, 6XQ8, 2LE9, 6XQ9, 4YBH, 2M1K, 4XYN, 6XQ7, 4OF5, 2MJW, 7LML, 3CJJ, 5D7F, 2ENS, 8I9M, 6VXG, 4OI7, 4OFV, 6XQ5, 2E5E, 4LP5, 2L7U, 6XQ6, 4OI8

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.719	5
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) MAPKAPK5 [nucleoplasm] (R-HSA-2562517) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018)	0.655	6
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.612	6
UniProt:O60610 DIAPH1	4	DIAPH1 [ficolin-1-rich granule membrane] (R-HSA-6801388) DIAPH1 [plasma membrane] (R-HSA-6801557) DIAPH1 [secretory granule membrane] (R-HSA-6801368) DIAPH1 [cytosol] (R-HSA-5665970)	0.581	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.558	9
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.558	2
UniProt:P23560-2 BDNF			0.556	3
UniProt:Q8WU43 CB015			0.556	3
UniProt:Q8N108-16 MIER1			0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:O43889-2 CREB3			0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.524	2
UniProt:Q01279	6	phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-MMU-8869138) phospho-p-4Y-EGFR [plasma membrane] (R-MMU-180287) phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (R-MMU-8864019) EGFR [plasma membrane] (R-MMU-179837) phospho-p-Y1086,Y1101-EGFR [plasma membrane] (R-MMU-179868) phospho-p-6Y-EGFR [plasma membrane] (R-MMU-179803)	0.524	2
UniProt:F1M775	4	Diaph1 [ficolin-1-rich granule membrane] (R-RNO-6801388) Diaph1 [plasma membrane] (R-RNO-6801557) Diaph1 [secretory granule membrane] (R-RNO-6801368) Diaph1 [cytosol] (R-RNO-5665970)	0.463	2
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.462	8
UniProt:Q9NWZ3 IRAK4	9	IRAK4 Q293* [cytosol] (R-HSA-5602426) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 E402* [cytosol] (R-HSA-5602517) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.462	4

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