Reactome | ROBO2 [plasma membrane]

ROBO2 [plasma membrane]

Stable Identifier

R-HSA-197747

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Roundabout homolog 2, ROB2_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9HCK4 ROBO2

Gene Names

ROBO2, KIAA1568

Chain

signal peptide:1-21, chain:22-1378

Reference Genes

BioGPS Gene:6092 ROBO2

COSMIC (genes):ROBO2 ROBO2

CTD Gene:6092 ROBO2

dbSNP Gene:6092 ROBO2

ENSEMBL:ENSG00000185008 ROBO2

ENSEMBL_homo_sapiens_GENE:ENSG00000185008.19 ROBO2

HGNC:10250 ROBO2

KEGG Gene (Homo sapiens):6092 ROBO2

Monarch:6092 ROBO2

NCBI Gene:6092 ROBO2

OMIM:602431 ROBO2

UCSC:Q9HCK4 ROBO2

Reference Transcript

Other Identifiers

11729986_a_at

11729987_s_at

11729988_x_at

16942743

226709_PM_at

226709_at

226766_PM_at

226766_at

240425_PM_x_at

240425_x_at

2630386

2630616

2630617

2630623

2630655

2630658

2630659

2630661

2630667

2630668

2630672

2630674

2630675

2630676

2630677

2630678

2630679

2630680

2630681

2630682

2630683

2630684

2630687

2630688

2630689

2630690

2630693

2630697

2630699

2630705

2630711

2630712

2630713

2630714

2630715

3050940

3050944

46520_at

6092

61677_at

63466_at

74892_r_at

8081001

A_24_P16326

A_24_P180151

A_33_P3278877

GE741721

GE83746

GE85425

GO:0001656

GO:0001657

GO:0003129

GO:0003148

GO:0003180

GO:0003184

GO:0003272

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006935

GO:0007155

GO:0007156

GO:0007399

GO:0007411

GO:0007417

GO:0007420

GO:0008046

GO:0009986

GO:0012501

GO:0016020

GO:0016199

GO:0021891

GO:0022414

GO:0023052

GO:0030154

GO:0030673

GO:0031290

GO:0032870

GO:0034330

GO:0035904

GO:0042802

GO:0043226

GO:0045747

GO:0048856

GO:0050772

GO:0050925

GO:0051964

GO:0060089

GO:0060412

GO:0061364

GO:0070062

GO:0098609

HMNXSV003040166

HMNXSV003054210

Hs.31141.0.S1_3p_at

Hs.31141.0.S2_3p_at

ILMN_1797926

ILMN_2189306

PH_hs_0033620

PH_hs_0035253

PH_hs_0035354

TC03000444.hg

TC03002402.hg

Participates

as a component of

as an input of

as a member of

as an output of

ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)

Inferred To

sdk [plasma membrane] (Drosophila melanogaster)

sax-3 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001276969.1, NP_001122401.1, NP_002933.1, NP_001276968.1, NP_001276994.1

OpenTargets

ENSG00000185008

HPA

ENSG00000185008-ROBO2

GeneCards

Q9HCK4

Ensembl

ENSP00000417164, ENST00000461745, ENST00000487694, ENSP00000417335, ENSG00000185008

PRO

Q9HCK4

Pharos - Targets

Q9HCK4

Orphanet

20716

PDB

5NOI, 6IAA, 1UEM, 2EDJ, 1UJT, 6I9S

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	5