Reactome | CD3E [plasma membrane]

CD3E [plasma membrane]

Stable Identifier

R-HSA-197906

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

T-cell surface glycoprotein CD3 epsilon chain precursor, CD3E_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07766 CD3E

Gene Names

CD3E, T3E

Chain

signal peptide:1-22, chain:23-207

Reference Genes

BioGPS Gene:916 CD3E

COSMIC (genes):CD3E CD3E

CTD Gene:916 CD3E

dbSNP Gene:916 CD3E

ENSEMBL:ENSG00000198851 CD3E

ENSEMBL_homo_sapiens_GENE:ENSG00000198851.10 CD3E

HGNC:1674 CD3E

KEGG Gene (Homo sapiens):916 CD3E

Monarch:916 CD3E

NCBI Gene:916 CD3E

OMIM:186830 CD3E

UCSC:P07766 CD3E

Reference Transcript

RefSeq:NM_000733.3 CD3E

Other Identifiers

11729855_at

16731795

205456_PM_at

205456_at

3351284

3351286

3351287

3351289

3351292

3351294

3351296

3351297

36277_at

7944179

916

A_14_P117535

A_23_P416747

A_24_P86968

GE60506

GO:0001772

GO:0001954

GO:0002250

GO:0002376

GO:0002669

GO:0002870

GO:0004888

GO:0005515

GO:0005783

GO:0005794

GO:0005886

GO:0005911

GO:0007155

GO:0007166

GO:0007169

GO:0007172

GO:0007186

GO:0007224

GO:0009897

GO:0010628

GO:0010629

GO:0012501

GO:0016020

GO:0016358

GO:0017124

GO:0019722

GO:0019901

GO:0021549

GO:0023052

GO:0030154

GO:0030159

GO:0031295

GO:0032729

GO:0032743

GO:0032753

GO:0033634

GO:0035739

GO:0036211

GO:0042098

GO:0042101

GO:0042102

GO:0042105

GO:0042106

GO:0042110

GO:0042608

GO:0042802

GO:0042981

GO:0043197

GO:0043226

GO:0044297

GO:0045059

GO:0045060

GO:0045879

GO:0046629

GO:0046631

GO:0046649

GO:0048856

GO:0050731

GO:0050850

GO:0050852

GO:0050870

GO:0060089

GO:0060090

GO:0065003

GO:0097190

GO:2000563

HMNXSV003040023

ILMN_1739794

M23323_s_at

PH_hs_0000378

TC11001060.hg

g4502670_3p_at

Participates

as a component of

Other forms of this molecule

p-Y188,Y199-CD3E [plasma membrane]

Inferred To

CD3E [plasma membrane] (Bos taurus)

CD3E [plasma membrane] (Canis familiaris)

CD3E [plasma membrane] (Gallus gallus)

CD3E [plasma membrane] (Sus scrofa)

Cd3e [plasma membrane] (Mus musculus)

Cd3e [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000724.1

Guide to Pharmacology - Targets

2742

OpenTargets

ENSG00000198851

GeneCards

P07766

HPA

ENSG00000198851-CD3E

Ensembl

ENSG00000198851, ENSP00000354566, ENST00000361763

PRO

P07766

Pharos - Targets

P07766

Orphanet

17286

PDB

8ES8, 7PHR, 8ES7, 7FJF, 8F0L, 1XIW, 1A81, 1SY6, 8ES9, 7FJD, 2ROL, 7FJE, 6JXR, 5QU2

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.737	6
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.675	4
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.597	6
UniProt:P43403 ZAP70	3	ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.527	3

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