Reactome | SCN3B [plasma membrane]

SCN3B [plasma membrane]

Stable Identifier

R-HSA-197921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel beta-3 subunit, CIB3_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNBs [plasma membrane] (Homo sapiens)
        
        SCN3B [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNBs [plasma membrane] (Homo sapiens)
        
        SCN3B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NY72 SCN3B

Gene Names

SCN3B, KIAA1158

Chain

signal peptide:1-22, chain:23-215

Reference Genes

BioGPS Gene:55800 SCN3B

COSMIC (genes):SCN3B SCN3B

CTD Gene:55800 SCN3B

dbSNP Gene:55800 SCN3B

ENSEMBL:ENSG00000166257 SCN3B

ENSEMBL_homo_sapiens_GENE:ENSG00000166257.10 SCN3B

HGNC:20665 SCN3B

KEGG Gene (Homo sapiens):55800 SCN3B

Monarch:55800 SCN3B

NCBI Gene:55800 SCN3B

OMIM:608214 SCN3B

UCSC:Q9NY72 SCN3B

Reference Transcript

Other Identifiers

11726423_a_at

11726424_x_at

11726425_a_at

16745583

204722_PM_at

204722_at

204723_PM_at

204723_at

3395684

3395685

3395687

3395689

3395690

3395692

3395693

3395694

3395696

3395700

3395706

3395707

3395711

3395712

3395713

3395714

41558_s_at

43044_at

45496_at

45658_at

55800

7952350

A_23_P116259

A_24_P312790

A_24_P381278

A_33_P3402404

GE53803

GE80728

GO:0001518

GO:0003012

GO:0003013

GO:0005215

GO:0005272

GO:0005515

GO:0005886

GO:0006811

GO:0006814

GO:0007399

GO:0010460

GO:0010765

GO:0016020

GO:0017080

GO:0019871

GO:0023052

GO:0030018

GO:0034220

GO:0034702

GO:0035725

GO:0043226

GO:0044325

GO:0048856

GO:0051899

GO:0055085

GO:0060048

GO:0060371

GO:0060373

GO:0061337

GO:0072659

GO:0086002

GO:0086005

GO:0086006

GO:0086010

GO:0086012

GO:0086014

GO:0086015

GO:0086091

GO:0098772

GO:2000649

HMNXSV003028774

HMNXSV003031672

HMNXSV003056629

Hs.4865.0.S3_3p_at

Hs.4865.0.S4_3p_at

ILMN_1700328

ILMN_2412822

PH_hs_0000493

TC11002396.hg

Participates

as a candidate of

SCNBs [plasma membrane] (Homo sapiens)

Inferred To

SCN3B [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_001035241.1, NP_060870.1, XP_011541199.1

OpenTargets

ENSG00000166257

GeneCards

Q9NY72

HPA

ENSG00000166257-SCN3B

Ensembl

ENST00000530277, ENST00000657191, ENST00000392770, ENSG00000166257, ENSP00000499755, ENSP00000499439, ENST00000657123, ENST00000299333, ENSP00000299333, ENSP00000376523, ENSP00000432785

PRO

Q9NY72

Pharos - Targets

Q9NY72

Orphanet

18901

HMDB Protein

HMDBP09083

PDB

4L1D, 7TJ8, 7TJ9

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.742	5
UniProt:P81534 DEFB103A	3	DEFB103A(1-67) [Golgi lumen] (R-HSA-975669) DEFB103A(23-67) [Golgi lumen] (R-HSA-1467243) DEFB103A(23-67) [extracellular region] (R-HSA-1467273)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:P22732 SLC2A5	2	SLC2A5 [plasma membrane] (R-HSA-189202) SLC2A5 [specific granule membrane] (R-HSA-6799571)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585) AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:Q96L58 B3GALT6	11	B3GALT6 [Golgi membrane] (R-HSA-913714) B3GALT6 G217S [Golgi membrane] (R-HSA-4420322) B3GALT6 S65G [Golgi membrane] (R-HSA-4420368) B3GALT6 M1? [Golgi membrane] (R-HSA-4420341) B3GALT6 R197Afs81 [Golgi membrane] (R-HSA-4420356) B3GALT6 R232C [Golgi membrane] (R-HSA-4420361) B3GALT6 D156N [Golgi membrane] (R-HSA-4420367) B3GALT6 C300S [Golgi membrane] (R-HSA-4420366) B3GALT6 D118Afs160 [Golgi membrane] (R-HSA-4420334) B3GALT6 D207H [Golgi membrane] (R-HSA-4420350) B3GALT6 P67L [Golgi membrane] (R-HSA-4420348)	0.527	3
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	2
UniProt:Q96K12 FAR2	1	FAR2 [peroxisomal membrane] (R-HSA-390430)	0.527	2
UniProt:Q6NUM9 RETSAT	1	RETSAT [endoplasmic reticulum membrane] (R-HSA-2980901)	0.527	3
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.527	2
UniProt:Q9UBQ6 EXTL2	1	EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.527	2
UniProt:Q5SRI9 MANEA	1	MANEA [Golgi membrane] (R-HSA-964729)	0.527	2
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.527	3
UniProt:P33897 ABCD1	8	ABCD1 R617C [peroxisomal membrane] (R-HSA-5685069) ABCD1 T77_L82del [peroxisomal membrane] (R-HSA-5685088) ABCD1 S606L [peroxisomal membrane] (R-HSA-5685104) ABCD1 [peroxisomal membrane] (R-HSA-382566) ABCD1 [cytosol] (R-HSA-382587) ABCD1 G277R [peroxisomal membrane] (R-HSA-5685058) ABCD1 M1V [peroxisomal membrane] (R-HSA-5685059) ABCD1 R554H [peroxisomal membrane] (R-HSA-5685072)	0.527	2
UniProt:Q99624 SLC38A3	1	SLC38A3 [plasma membrane] (R-HSA-352171)	0.527	2
UniProt:Q9P244 LRFN1	1	SALM2 [plasma membrane] (R-HSA-204734)	0.527	3
UniProt:Q9Y672 ALG6	3	ALG6 A333V [endoplasmic reticulum membrane] (R-HSA-4724295) ALG6 S478P [endoplasmic reticulum membrane] (R-HSA-4724296) ALG6 [endoplasmic reticulum membrane] (R-HSA-449645)	0.527	2
UniProt:Q9BVK2 ALG8	5	ALG8 [endoplasmic reticulum membrane] (R-HSA-449640) ALG8 T138Kfs19 [endoplasmic reticulum membrane] (R-HSA-4724312) ALG8 V133Sfs3 [endoplasmic reticulum membrane] (R-HSA-4724313) ALG8 T47P [endoplasmic reticulum membrane] (R-HSA-4724334) ALG8 G275D [endoplasmic reticulum membrane] (R-HSA-4724304)	0.527	2
UniProt:Q70CQ3 USP30	2	USP30 [mitochondrial outer membrane] (R-HSA-5696931) USP30 [peroxisomal membrane] (R-HSA-9674135)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:O15440 ABCC5	1	ABCC5 [plasma membrane] (R-HSA-1454939)	0.527	2

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