Reactome | MCAM [plasma membrane]

MCAM [plasma membrane]

Stable Identifier

R-HSA-197922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cell surface glycoprotein MUC18 precursor, MU18_HUMAN, CD146

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P43121 MCAM

Gene Names

MCAM, MUC18

Chain

signal peptide:1-23, chain:24-646

Reference Genes

BioGPS Gene:4162 MCAM

COSMIC (genes):MCAM MCAM

CTD Gene:4162 MCAM

dbSNP Gene:4162 MCAM

ENSEMBL:ENSG00000076706 MCAM

HGNC:6934 MCAM

Monarch:4162 MCAM

NCBI Gene:4162 MCAM

OMIM:155735 MCAM

UCSC:P43121 MCAM

Reference Transcript

RefSeq:NM_006500.2 MCAM

Other Identifiers

11724459_x_at

11724460_a_at

16745281

209086_PM_x_at

209086_x_at

209087_PM_x_at

209087_x_at

210869_PM_s_at

210869_s_at

211340_PM_s_at

211340_s_at

3394268

3394269

3394270

3394271

3394272

3394273

3394274

3394275

3394276

3394277

3394279

3394280

3394282

3394283

3394284

3394285

3394286

3394287

3394288

3394289

3394290

3394291

3394292

3394293

3394294

3394295

3394296

3394297

3394298

3394299

3394300

3394301

3394302

3394303

3394304

3394305

4162

7952205

87991_at

A_23_P162171

A_24_P326660

GE61063

GE63318

GO:0001525

GO:0003014

GO:0003094

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0007155

GO:0009653

GO:0009897

GO:0016020

GO:0030335

GO:0061042

HMNXSV003016057

HMNXSV003032594

Hs.211579.2.S1_3p_a_at

ILMN_1685275

M28882_s_at

M29277_s_at

PH_hs_0026600

TC11002366.hg

g4336423_3p_a_at

Participates

as a candidate of

Inferred To

Mcam [plasma membrane] (Mus musculus)

Mcam [plasma membrane] (Rattus norvegicus)

MCAM [plasma membrane] (Bos taurus)

MCAM [plasma membrane] (Canis familiaris)

MCAM [plasma membrane] (Dictyostelium discoideum)

MCAM [plasma membrane] (Gallus gallus)

MCAM [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2988

ENSEMBL

ENST00000264036, ENSP00000264036

OpenTargets

ENSG00000076706

HPA

ENSG00000076706-MCAM

PRO

P43121

Pharos - Targets

P43121

GlyGen

P43121

HMDB Protein

HMDBP07819

PDB

6LYN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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