Reactome | INPP5D [cytosol]

INPP5D [cytosol]

Stable Identifier

R-HSA-197940

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHIP1, O00145_HUMAN

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External Reference Information

External Reference

UniProt:Q92835 INPP5D

Gene Names

INPP5D, SHIP, SHIP1

Chain

chain:1-1189

Reference Genes

BioGPS Gene:3635 INPP5D

COSMIC (genes):INPP5D INPP5D

CTD Gene:3635 INPP5D

dbSNP Gene:3635 INPP5D

ENSEMBL:ENSG00000168918 INPP5D

ENSEMBL:ENSG00000168918.14 INPP5D

ENSEMBL:ENSG00000281614.3 INPP5D

HGNC:6079 INPP5D

KEGG Gene (Homo sapiens):3635 INPP5D

Monarch:3635 INPP5D

NCBI Gene:3635 INPP5D

OMIM:601582 INPP5D

UCSC:Q92835 INPP5D

Reference Transcript

Other Identifiers

0000360068

11733123_s_at

11744363_s_at

11744364_s_at

11752467_s_at

16892446

172_at

203331_PM_s_at

203331_s_at

203332_PM_s_at

203332_s_at

2532700

2532701

2532706

2532707

2532726

2532730

2532731

2532739

2532741

2532742

2532745

2532747

2532749

2532751

2532753

2532754

2532755

2532757

2532758

2532759

2532760

2532761

2532767

2532769

2532770

2532771

2532772

3635

8049246

A_14_P128062

A_23_P61149

GE62309

GO:0002376

GO:0003824

GO:0004439

GO:0004445

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006629

GO:0006661

GO:0006796

GO:0006915

GO:0007165

GO:0008340

GO:0009966

GO:0009968

GO:0012501

GO:0016020

GO:0016064

GO:0016314

GO:0016787

GO:0016791

GO:0017124

GO:0019637

GO:0023052

GO:0030154

GO:0030853

GO:0030889

GO:0032715

GO:0034485

GO:0035556

GO:0043065

GO:0043226

GO:0045121

GO:0045579

GO:0045621

GO:0045648

GO:0045656

GO:0045659

GO:0045671

GO:0045779

GO:0046856

GO:0048856

GO:0050776

GO:0050777

GO:0050852

GO:0050869

GO:0052658

GO:0052659

ILMN_1676783

ILMN_1744212

ILMN_1749920

PH_hs_0023310

TC02001414.hg

U57650_at

g4097284_3p_a_at

g5031798_3p_a_at

Participates

as an input of

as a component of

PECAM-1:SHIP1 complex [plasma membrane] (Homo sapiens)

as a member of

Other forms of this molecule

p-Y-INPP5D [cytosol]

Inferred To

si:ch73-194h10.1 [cytosol] (Danio rerio)

Homologues of INPP5D [cytosol] (Danio rerio)

Inpp5d [cytosol] (Mus musculus)

Inpp5d [cytosol] (Rattus norvegicus)

INPP5D [cytosol] (Bos taurus)

INPP5D [cytosol] (Canis familiaris)

INPP5D [cytosol] (Gallus gallus)

INPP5D [cytosol] (Sus scrofa)

inpp5d [cytosol] (Danio rerio)

inpp5d [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005532.2, NP_001017915.1

Guide to Pharmacology - Targets

1455

OpenTargets

ENSG00000168918

IntEnz

3.1.3.86

GeneCards

Q92835

HPA

ENSG00000168918-INPP5D

Ensembl

ENST00000630854, ENSP00000486669, ENSP00000487191, ENST00000445964, ENSG00000281614, ENST00000359570, ENSP00000352575, ENSG00000168918, ENST00000629761, ENSP00000405338

PRO

Q92835

Pharos - Targets

Q92835

HMDB Protein

HMDBP03787

PDB

5RWC, 5RXO, 5RWT, 5RY8, 5RXX, 6XY7, 5RWL, 5RXW, 5RYH, 5RY7, 5RXY, 5RY9, 5RWD, 5RY0, 5RWM, 5RWE, 5RXP, 5RXG, 5RX7, 5RY1, 5RXQ, 5RYJ, 5RW7, 5RWW, 5RX8, 5RYA, 5RXH, 5RW8, 5RXR, 5RWX, 5RWP, 5RYB, 5RXJ, 5RX0, 5RXI, 5RX9, 5RW9, 5RWQ, 5RWH, 5RYK, 5RYC, 5RY4, 5RWI, 5RY6, 5RWR, 5RWA, 5RXC, 5RYD, 5RW2, 5RY5, 5RXD, 5RW3, 6IBD, 5RXM, 5RYE, 5RX4, 5RXE, 5RW4, 5RYF, 5RX5, 5RWU, 5RW5, 5RYG, 5RXF, 5RWV, 5RW6, 5RWN, 5RXZ, 5RX6, 5RWF, 5RWO, 5RYI, 5RY2, 5RWG, 5RXT, 5RY3, 5RYL, 5RWY, 5RXS, 5RX1, 5RXA, 5RWZ, 5RXK, 5RXV, 5RXL, 5RXB, 5RXU, 5RX2, 5RX3, 5RWS, 5RWJ, 2YSX, 5RWK, 5RWB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31994 FCGR2B	1	FCGR2B [plasma membrane] (R-HSA-197854)	0.702	3
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.667	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:P19235 EPOR	2	EPOR [plasma membrane] (R-HSA-1168347) p-8Y-EPOR [plasma membrane] (R-HSA-9006274)	0.547	2
UniProt:Q13291 SLAF1			0.462	2