Reactome | NCK1 [cytosol]

NCK1 [cytosol]

Stable Identifier

R-HSA-197954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cytoplasmic protein NCK1, NCK1_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - DCC mediated attractive signaling (Homo sapiens)
        
        Activation of Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Activation of Rac1 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        DCC interacting NCK-1 (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Recruitment of ABLIM to the plasma membrane (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP:ABLIM [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        RhoGTPase GEF's recruited to DCC (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Activation of RAC1 (Homo sapiens)
        
        Activation of RAC1 by SOS (Homo sapiens)
        
        SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        NCK binds ROBO1:SLIT2 (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Recruitment of PAK to NCK (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Recruitment of SOS to plasma membrane (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
        
        SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WIP binds WASP,N-WASP, activating them (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        BTK binds BTK inhibitors (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - Downstream signal transduction (Homo sapiens)
      - Nck binds to the active PDGF receptor (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - CDC42:GTP binds PAK2 (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - FYN autophosphorylates (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - FYN phosphorylates PAK2 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - PAK2 autophorylates (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - PAK2 binds NCK (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - p-6Y-VEGFR2 binds FYN (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - p-6Y-VEGFR2 binds NCK (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - p-Y420-FYN is phosphorylated on S21 (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - p38 MAPK activation by VEGFR (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
        
        NCK1,NCK2 [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        WIP binds WASP,N-WASP, activating them (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOU GTPase cycle (Homo sapiens)
        
        RHOU binds effectors at the plasma membrane (Homo sapiens)
        
        RHOU effectors [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
        
        RHOU effectors [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
      - RHOV GTPase cycle (Homo sapiens)
        
        RHOV binds effectors at the plasma membrane (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16333 NCK1

Gene Names

NCK1, NCK

Chain

initiator methionine:, chain:2-377

Reference Genes

COSMIC (genes):NCK1 NCK1

dbSNP Gene:4690 NCK1

ENSEMBL:ENSG00000158092 NCK1

Participates

as a candidate of

as an input of

as a component of

as a member of

Other forms of this molecule

NCK1 [plasma membrane]

Inferred To

Nck1 [cytosol] (Mus musculus)

Nck1 [cytosol] (Rattus norvegicus)

NCK1 [cytosol] (Bos taurus)

NCK1 [cytosol] (Canis familiaris)

NCK1 [cytosol] (Drosophila melanogaster)

NCK1 [cytosol] (Sus scrofa)

nck1b [cytosol] (Danio rerio)

Ghost homologue of NCK1 [cytosol] (Gallus gallus)

nck1 [cytosol] (Xenopus tropicalis)

nck-1 [cytosol] (Caenorhabditis elegans)

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.881	21
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.823	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.775	6
UniProt:P07766 CD3E	2	p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228) CD3E [plasma membrane] (R-HSA-197906)	0.737	6
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.704	4
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.69	11
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.688	6
UniProt:Q07912 TNK2	1	TNK2 [cytosol] (R-HSA-9842568)	0.688	3
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.672	6
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.669	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.65	5
UniProt:Q92918 M4K1			0.646	4
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	5
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.609	2
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	6
UniProt:Q5WMC9 Q5WMC9			0.584	4
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.573	4
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.571	3
UniProt:O15117 FYB	1	FYB [cytosol] (R-HSA-390925)	0.564	3
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.564	4
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.564	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.564	2
UniProt:O43150 ASAP2			0.564	2
UniProt:O14513 NCKP5			0.564	2
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.564	3
UniProt:Q6ZUJ8-3 PIK3AP1			0.556	3
UniProt:Q9Y2H0-1 DLGAP4			0.556	3
UniProt:P52757 CHN2	1	CHN2 [cytosol] (R-HSA-2980572)	0.556	3
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:Q9P206 NHSL3			0.547	4
UniProt:P10912 GHR	7	GHR activated [plasma membrane] (R-HSA-1168385) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [endosome lumen] (R-HSA-1169263) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226)	0.536	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.527	4
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	4
UniProt:Q9HCH3 CPNE5			0.527	2
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.527	3
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.527	3
UniProt:O60500 NPHS1	2	p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636) NPHS1 [plasma membrane] (R-HSA-8981500)	0.524	3
UniProt:Q05193 DNM1	3	DNM1 [plasma membrane] (R-HSA-177488) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [cytosol] (R-HSA-2213182)	0.524	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.499	3
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q8TAK6 OLIG1			0.488	2

Cite Us!