Reactome | NCK1 [cytosol]

NCK1 [cytosol]

Stable Identifier

R-HSA-197954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cytoplasmic protein NCK1, NCK1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O00401

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - DCC mediated attractive signaling (Homo sapiens)
        
        DCC interacting NCK-1 (Homo sapiens)
        
        NCK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16333 NCK1

Gene Names

NCK1, NCK

Chain

initiator methionine:1, chain:2-377

Reference Genes

BioGPS Gene:4690 NCK1

COSMIC (genes):NCK1 NCK1

CTD Gene:4690 NCK1

dbSNP Gene:4690 NCK1

ENSEMBL:ENSG00000158092 NCK1

HGNC:7664 NCK1

KEGG Gene (Homo sapiens):4690 NCK1

Monarch:4690 NCK1

NCBI Gene:4690 NCK1

OMIM:600508 NCK1

UCSC:P16333 NCK1

Reference Transcript

Other Identifiers

0000610348

11729219_at

16946063

204725_s_at

211063_s_at

236922_at

244487_at

2644156

2644157

2644165

2644168

2644170

2644171

2644172

2644175

2644176

2644177

2644178

2644179

2644195

2644197

2644199

41795_at

4690

77058_at

8082911

81605_at

989_at

A_14_P126342

A_23_P255785

GE59747

GE598177

GO:0000164

GO:0002376

GO:0003674

GO:0004860

GO:0005070

GO:0005102

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005886

GO:0005911

GO:0006412

GO:0006417

GO:0006464

GO:0006469

GO:0006810

GO:0006930

GO:0006950

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0007172

GO:0008092

GO:0008093

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0010976

GO:0012506

GO:0016192

GO:0016477

GO:0019899

GO:0019904

GO:0022607

GO:0030032

GO:0030154

GO:0030159

GO:0030234

GO:0030334

GO:0030674

GO:0030838

GO:0030971

GO:0032991

GO:0033137

GO:0034641

GO:0035591

GO:0036493

GO:0038096

GO:0040011

GO:0042102

GO:0042110

GO:0043226

GO:0045296

GO:0045944

GO:0046627

GO:0046875

GO:0048010

GO:0048013

GO:0048856

GO:0048870

GO:0050852

GO:0051707

GO:0060548

GO:0065003

GO:0070262

GO:0071074

GO:1902237

GO:1903676

GO:1903679

GO:1903898

GO:1903912

GO:1990441

Hs.121645.0.A1_3p_at

Hs.126889.0.A1_3p_at

Hs.126889.0.A1_3p_x_at

ILMN_1698001

ILMN_1778367

ILMN_1821397

PH_hs_0007246

PH_hs_0027654

TC03003323.hg

X17576_at

g13623576_3p_s_at

g5453753_3p_s_at

Participant Of

hasMember

input

hasComponent

Other forms of this molecule

NCK1 [plasma membrane]

Inferred To

dock [cytosol] (Drosophila melanogaster)

Nck1 [cytosol] (Mus musculus)

Nck1 [cytosol] (Rattus norvegicus)

NCK1 [cytosol] (Bos taurus)

NCK1 [cytosol] (Canis familiaris)

NCK1 [cytosol] (Sus scrofa)

nck1b [cytosol] (Danio rerio)

nck1 [cytosol] (Xenopus tropicalis)

nck-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001177725.1, NP_006144.1, NP_001278928.1

OpenTargets

ENSG00000158092

HPA

ENSG00000158092-NCK1

GeneCards

P16333

ZINC target

P16333

Ensembl

ENST00000469404, ENSP00000417273, ENSG00000158092, ENST00000288986, ENSP00000419631, ENSP00000288986, ENST00000481752

PRO

P16333

PDB

5QUA, 2CI8, 5QU5, 2CI9, 2CUB, 5QU6, 5QU1, 5QU2, 2JS0, 2JW4, 5QU7, 5QU3, 5QU8, 2JS2, 5QU4

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.884	21
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.773	5
UniProt:P07766 CD3E	2	p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228) CD3E [plasma membrane] (R-HSA-197906)	0.737	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709)	0.709	5
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.672	6
UniProt:Q92918 M4K1			0.646	4
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.611	3
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	6
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.597	10
UniProt:Q07912 ACK1			0.59	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.589	4
UniProt:P10912 GHR	7	GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.589	3
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.589	5
UniProt:Q5WMC9 Q5WMC9			0.584	4
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.573	4
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.571	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.564	2
UniProt:O15117 FYB1	1	FYB [cytosol] (R-HSA-390925)	0.564	3
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:P52757 CHN2	1	CHN2 [cytosol] (R-HSA-2980572)	0.556	3
UniProt:Q9Y2H0-1 DLGAP4			0.556	3
UniProt:Q6ZUJ8-3 PIK3AP1			0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	3
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.524	2
UniProt:O60500 NPHS1	2	NPHS1 [plasma membrane] (R-HSA-8981500) p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636)	0.524	3
UniProt:Q15208 STK38			0.499	3
UniProt:P35968 KDR	4	VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.499	3
UniProt:Q8TAK6 OLIG1			0.488	2
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2

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