Folate is reduced to dihydrofolate (DHF)

Stable Identifier
R-HSA-197963
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic dihydrofolate reductase catalyzes the reaction of folate, NADPH, and H+ to form dihydrofolate and NADP+ (Chen et al. 1984; Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW

J Biol Chem 1984
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Davies JF, 2nd, Delcamp, TJ, Prendergast, NJ, Ashford, VA, Freisheim, JH, Kraut, J

Biochemistry 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
folate reductase activity of DHFR [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea